Twist Universal Blockers by Twist Bioscience

In targeted next-generation sequencing (NGS), a blocking solution is used during probe hybridization to prevent non-specific hybridization between target enrichment probes and adapter sequences. Twist Universal blockers are designed to block multiple TruSeq-compatible barcode sequences and adapter lengths. They can accommodate multiple projects and applications, eliminating the need to purchase multiple blocker products for TruSeq-compatible adapters with varied index designs.

KEY BENEFITS

Flexible Blocking Solution

• No need for adapter-specific blockers — blocks many different adapter designs
• Effective across singleplex and multiplex target enrichment workflows  
• Improves on-target capture regardless of panel size

Improved On-Target Capture

• Prevents cross-hybridization between TruSeq-compatible adapters
• Enhances the performance of target enrichment workflows

Maximized Efficiency

• Ready-to-use formulation
• Reduces per-sample sequencing cost