Thermo Scientific™ ProPac™ SCX and WCX Protein Column
Strong and Weak Cation-Exchange Columns for High-Resolution Separation of Proteins and MAbsThe Thermo Scientific ProPac™ SCX column line has expanded to include the next generation ProPac SCX-20 column. This column provides unequalled high resolution of protein variants.ProPac SCX-10 and WCX-10 strong and weak cation-exchange columns are based on a nonporous core particle that results in high-efficiency peaks and high-resoluti…
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Strong and Weak Cation-Exchange Columns for High-Resolution Separation of Proteins and MAbs
The Thermo Scientific ProPac™ SCX column line has expanded to include the next generation ProPac SCX-20 column. This column provides unequalled high resolution of protein variants.
ProPac SCX-10 and WCX-10 strong and weak cation-exchange columns are based on a nonporous core particle that results in high-efficiency peaks and high-resolution separations of protein variants. A hydrophilic layer prevents unwanted secondary interactions. A grafted cation-exchange surface provides pH-based selectivity control and fast mass transfer for high-efficiency separation and moderate capacity.
ProPac® SCX and WCX Protein Column Features:
- Characterization and quality control assessment of monoclonal antibodies and other proteins
- Unequalled resolution
- High-resolution separations with excellent sample recovery
- Unmatched column-to-column and lot-to-lot reproducibility
- Useful for characterization of related protein variants (e.g., deamidation and MAb lysine truncation variants)
- Highly-efficient peaks with excellent sample recovery
- Available in different dimensions and formats for flexibility in method development
Column Details:
- Length: 50, 100, 150, 250 mm
- ID: 2.0, 4.0, 9.0, 22 mm
High-Throughput, High-Resolution Monoclonal Antibody Analysis with Small Particle Size HPLC Columns
This application note shows the selectivity differences between ProPac WCX-10 and MAbPac SCX-10 phases for protein separation. Applications using smaller particle columns for high-throughput, high-resolution mAb separations are also described. The ruggedness of small particle phase columns is also presented.
Separation of Intact Monoclonal Antibody Sialylation Isoforms by pH Gradient Ion-Exchange Chromatography
This application note demonstrates high-resolution separation of intact protein sialylation isoforms using the Thermo Scientific™ ProPac™ SCX-10 column on a Thermo Scientific™ Dionex™ UltiMate™ 3000 Dual BioRS LC System with a salt or pH gradient.
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