CIMmultus OH
A tool for chromatographic purification of LNPs as an alternative to filtration methods.
Place your order directly with the manufacturer.
CIMmultus® OH is a hydroxyl-functionalized monolithic chromatography column designed for hydrophobic interaction chroamtography (HIC). Its non-specific, hydrophilic surface enables the gentle removal of impurities such as unencapsulated nucleic acids, ethanol from encapsulation and formulation buffers, and other process-related contaminants—without affecting LNP structure or cargo integrity. In a high-recovery manner, it achieves the same goals as TFF and dialysis, by collecting hihgly purified and concentrated particles. The added benefits of removing impurities elevates this method above the existing methods.
The column leverages monolith technology for convective flow, allowing for high flow rates and low backpressure, even with viscous formulations. This makes CIMmultus® OH particularly suitable for scalable, high-throughput LNP purification, from early development to commercial production. Its broad binding profile and mild operating conditions support platform approaches and method development across a range of LNP modalities.
Key Features & Benefits
- A purification of LNPs beyond filtration to enhance LNP formulations.
- Removes unencapsulated cargo, ethanol and formulation buffers to achieve buffer exchange and concentration.
- Operates under mild buffer conditions to preserve LNP structure and cargo.
- Produces particles of high quality.
Applications
- Downstream processing of LNP formulations post-encapsulation.
- Purifiying complex LNP Biopharmaceuticals for in vivo CAR-T and CRISPR applications.
- Purifiying targeted LNPs.
- Removal of unencapsulated mRNA, siRNA, or small molecules
- Downstream processing of mRNA vaccines and gene therapy products
- Process development and platform method evaluation
- Scalable purification for clinical and commercial manufacturing
Revealing hidden LNP subpopulations with high‑resolution chromatographic techniques
Tuesday, May 26 at 16:00 BST | 17:00 CEST | 11:00 EDT | 8:00 PDT
As lipid nanoparticle (LNP)-based therapeutics diversify and regulatory expectations for complex nucleic acid products mature, analytical strategies must evolve. Modern LNP characterization now requires integrated workflows that can simultaneously assess particle size, quantify payload, and detect critical impurities.
In this SelectScience® webinar, Dr. Mojca Tajnik Sbaizero, a specialist with 10 years of experience in downstream processing for viral and non‑viral delivery, will be joined by Tristan Kovačič, who leads formulation development for non‑viral nucleic acid delivery at Sartorius BIA Separations. Together, they will demonstrate how emerging chromatographic platforms enable multi‑parameter LNP characterization and support robust, scalable analytical strategies across diverse delivery systems. They will also show how these same approaches help generate functional, uniform LNP particles for final drug product development.
As LNP complexity increases, these experts will outline the growing need to separate distinct particle subpopulations and explain how advanced chromatographic separations enhance consistency, safety, and overall product understanding, ultimately strengthening progress in drug development.
Certificate of attendance
If you attend the live webinar, you will automatically receive a certificate of attendance, including a learning outcomes summary, for continuing education purposes. If you view the on-demand webinar, you can request a certificate of attendance by emailing editor@selectscience.net.
Webinar details
- Cost: Free to attend
- Location: Online
- Duration: 60 minutes
Registration is required to secure your place. If you register but can’t attend live, you will receive a link to the on‑demand recording once it becomes available.
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