Supel™Genie Online SPE Cartridges
Supel ™ Genie Online SPE cartridges are a sample preparation solution that offer a seamless workflow from start to finish performed entirely 'online' the LC instrument. Typically, an autosampler would take the samples from a collection plate or tubes, and inject them directly onto the SPE cartridge located on the analytical instrument (LC instrument). This enables an entirely hands free workflow which eliminates the risk o…
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Supel™ Genie Online SPE cartridges are a sample preparation solution that offer a seamless workflow from start to finish performed entirely 'online' the LC instrument. Typically, an autosampler would take the samples from a collection plate or tubes, and inject them directly onto the SPE cartridge located on the analytical instrument (LC instrument). This enables an entirely hands free workflow which eliminates the risk of human error as the most critical, labor intensive steps of the process are now automated.
Some of the many benefits of Online SPE:
- Eliminates human error and reduces labor costs
- Automation accommodates much higher throughput levels than manual prep
- Even if currently performing automated offline sample prep, there is still a transfer step to LC instrument
- Decreased cost per sample (reduced labor and increased throughput)
- Less space - one cartridge vs. hundreds of individual cartridges or multiple 96-well plates (online cartridges much smaller than individual SPE tubes)
Removal of Phospholipids from Protein Precipitated Biological Fluid Samples, for LC-MS/MS Analysis
Phospholipids (PL) are present in many biological samples, including blood and cerebral spinal fluid. However, they are notorious for co-extracting with a broad range of analytes and therefore compromising LC-MS-based analyses. They can cause ion supression, ion enhancement, and even limit the lifespan of reversed phase columns. This application note demonstrates how HybridSPE® phospholipid technology has been developed for selective and rapid PL depletion. Originally published in Supelco®'s Analytix Reporter Journal Issue 2 2018 by Merck KGaA, Darmstadt, Germany. Visit SigmaAldrich.com/ar-reg.
