SeQuant® ZIC®-cHILIC for HPLC and LC-MS separation of polar hydrophilic compounds
This new zwitterionic stationary phase with phosphorylcholine functional group provides you with complementary selectivity for easier method development for substances that have been difficult to separate by previous types of HPLC columns operated in reversed-phase or HILIC mode. The selectivity features of SeQuant® ZIC®-cHILIC are especially beneficial for negatively charged polar compounds such as nucleotides and organic…
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This new zwitterionic stationary phase with phosphorylcholine functional group provides you with complementary selectivity for easier method development for substances that have been difficult to separate by previous types of HPLC columns operated in reversed-phase or HILIC mode.
The selectivity features of SeQuant® ZIC®-cHILIC are especially beneficial for negatively charged polar compounds such as nucleotides and organic acids, but do also provide advantageous separations of positively charged hydrophilic molecules; for example aminoglycosides and cations. The column is also very suitable for zwitterionic and neutral polar hydrophilic substances.
- High-performance HILIC column
- Complementary selectivity for polar hydrophilic compounds
- Maximum LC-MS compatibility with minimized column bleed
- Excellent reproducibility and robustness
- Very high stability (more than 1600 injections during 270 hours of continuous use without showing any signs of change in retention)
Complementary Selectivity for HPLC and LC-MS Separation of Polar Hydrophilic Compounds with SeQuant® ZIC®-cHILIC from Merck Millipore
This brochure describes the advantages of using SeQuant ZIC-cHILIC for HPLC and LC-MS of polar hydrophilic compounds. This new zwitterionic stationary phase provides you with complementary selectivity for easier method development for substances that have been difficult to separate by previous types of HPLC columns operated in reversed-phase or HILIC mode.
Solutions for Mass Spectrometric Detection from Merck Millipore
Mass spectrometry (MS) is nowadays an established routine detection method that can be coupled to various techniques in the laboratory. In contrast to more simple detectors such as ultraviolet-visible (UV-Vis) or fluorescence, MS generates data about molecular masses and detailed structural parameters and is by far more sensitive in the wide majority of applications. Many sophisticated as well as affordable systems are available, covering various fields of use such as quantification and qualification experiments, and a number of these systems are described in this compendium.
