QSight® Triple Quadrupole LC/MS/MS

Pesticides are a group of compounds containing hundreds of listed substances, most of which are regulated by governmental agencies. Their function is to prevent, destroy, or control harmful organisms or diseases, as well as protect plants or plant products during production, storage and transport. The European Commission (EC) has set maximum residue limits (MRLs) for pesticide residues in or on food and feed of plant and animal origin, as detailed in legislative framework Regulation (EC) 396/2005. MRLs vary for given pesticides and food products, but generally, the MRLs are set at 0.01 mg/kg for many fruits and vegetables. In this application note, learn more about a fast, sensitive, and selective multi-residue method. Described for the analysis of 503 pesticides in fruit and vegetable matrices, this method utilizes a QSight® 220 triple quadrupole mass detector coupled to the LX50 ultra-high performance liquid chromatography (UHPLC) system.

Acrylamide has gained notoriety over the past years as it can cause certain cancers. Polyacrylamides are often used as flocculants in the water clarification process and can lead to the leaching of the monomer acrylamide into our drinking water systems. In this application note, discover the benefits of the dual source capability of the PerkinElmer QSight™ Triple Quadrupole LC/MS/MS for a sensitive determination of organic contaminants in water samples that require different ionization techniques. Further, explore how using the QSight LC/MS/MS dual source can provide a simpler, faster, and more sensitive method for contaminants in water with method improvements compliant to current European regulations.

Growing health concerns regarding per- and polyfluoroalkyl (PFAS) and their prevalence in consumer goods and the environment indicates a critical need to perform existing and upcoming regulatory methods efficiently and reliably on commercially available instrumentation. This application note focuses on the validation of EPA Method 533, as well as the development of an improved version of this methodology using the PerkinElmer QSight® LX50 Ultra High-Performance Liquid Chromatography coupled with the PerkinElmer QSight® 210 Triple Quadrupole Mass Spectrometer.

Methylmalonic acid (MMA) and 3-hydroxypropionic (3OHPA) are two biomarkers used to study propionylcarnitine related disorders. A reliable determination of MMA and 3OHPA is challenging because of the low volume of sample available such as dry blood spots (DBS) which require very sensitive detection technology. LC-MS based method has demonstrated the ability to provide selectivity and sensitivity needed.

In this application note from PerkinElmer, discover how scientists approached this challenge developing a simple sample extraction from DBS coupled with a short chromatographic separation to resolve and quantify MMA and 3OHPA, all using QSight LC/MS/MS.

In apiculture, sulfonamides are the most commonly used antibiotics to treat American and European foulbrood, a type of disease that infects bees. This can result in bee honey being contaminated with sulfonamides.To help combat this, developing a fast, reliable and robust method for the quantitation of sulphonamides in honey is therefore very important. This application note presents a sulphonamide quantitation method using PerkinElmer's QSight® 210 System.

The QSight™ Triple Quad delivers the high sensitivity and reliability, discover the key features of the 200 model in this video interview with Kaveh Kahen of PerkinElmer. What’s more, its flow-based system is built around unique technology that enables 15% higher throughput than conventional systems. From method development to results and reporting, the QSight triple quad is easy-to-use and maintain so you can run more samples in less time.

Find out how LC-MS technology is being used to quantify the experimental drug remdesivir

High throughput mass spectrometry-based clinical solution can run hundreds of samples per day