Prometheus Panta system for stability characterization of biologics by NanoTemper Technologies


Collect data on thermal unfolding, particle sizing, and aggregation simultaneously throughout the entire thermal ramp for high-resolution, domain-specific stability characterization of biologics.


Prometheus Panta system for stability characterization of biologics by NanoTemper Technologies product image
Prometheus Panta system for stability characterization of biologics

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Features:

  • High-resolution data that reveals liabilities in drug candidates
  • Domain-specific information about your candidate molecule when you measure thermal unfolding, particle sizing, and aggregation simultaneously throughout the entire thermal ramp
  • Flexible throughput and a few choices for sample handling

Parameters that Prometheus Panta measures

Dynamic Light Scattering (DLS)
SIZE ANALYSIS

  • Tsize (from growth of rH in cumulants fit)
    • Temperature at which average particle size begins to increase
  • Tscattering (from scattering intensity)
    • Fragments, PROTACs, ions, nanoparticles, peptides, and carbohydrates
  • Average scattering intensity
    • Identifies if concentration is too high or low for proper size distribution analysis

CUMULANT OR SIZE DISTRIBUTION/REGULARIZATION ANALYSIS

  • rH
    • Hydrodynamic radius shows size of particle in solvated state
  • PDI
    • Polydispersity index represents distribution of size populations

SELF-INTERACTION ANALYSES

  • kD
    • Diffusion interaction identifies onset of unfolding and impact on colloidal stability
  • D0 determined from the kD analysis
    • Theoretical diffusion constant at concentration = 0

nanoDSF
THERMAL UNFOLDING

  • Tm (for 330 nm, 350 nm, and ratio)
    • Melting temperature, or point at which 50% is unfolded
  • Tonset (for ratio)
    • Temperature at which unfolding begins
  • Ea (*parameter derived from data)
    • Activation energy of unfolding
  • Reversibility of unfolding
    • Point at which irreversibility happens when unfolding

Backreflection
AGGREGATION

  • Tturbidity
    • Onset temperature of aggregation

Product Overview

Prometheus Panta system for stability characterization of biologics by NanoTemper Technologies product image

Prometheus Panta system for stability characterization of biologics

Manufacturer NanoTemper Technologies

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