Use of self-interaction parameters derived from light scattering experiments for better developability assessment of biologic therapeutics

20 Sept 2022

In this application note, NanoTemper Technologies demonstrates how the Prometheus Panta measures self-interaction of proteins and allows researchers to prioritize candidates and improve outcomes.

Prometheus Panta for biologics stability profiling with particle sizing and molecular weight determination by NanoTemper Technologies

NanoTemper Technologies

Prometheus Panta monitors the thermal stability, turbidity, and dispersity of a protein sample, and provides the highest-resolution, highest-quality data for ranking and selecting candidates. Prometheus Panta outputs critical quality parameters about your therapeutic proteins of interest, including: their hydrodynamic radius, molecular weight, self-association propensity, and deltaG of unfolding.

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Use of self-interaction parameters derived from light scattering experiments for better developability assessment of biologic therapeutics