Olink Explore® 384 Oncology by Olink Proteomics

Manufacturer Olink Proteomics  |  Available Worldwide
The most comprehensive, high-performance protein biomarker panel available for oncology studies

Olink Explore<sup>®</sup> 384 Oncology by Olink Proteomics product image
Olink Explore® 384 Oncology
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Olink® Explore 384 Oncology is a high-multiplex, high-throughput protein biomarker platform that uses Proximity Extension Assay (PEA) technology coupled to an innovative new readout methodology based on Next Generation Sequencing (NGS) using the Illumina® NovaSeq instrument.

PEA uses matched pairs of antibodies (Abs) attached to unique DNA oligonucleotides. When the correct pair simultaneously binds to a target protein, their DNA oligonucleotides hybridize and serve as a unique template for DNA polymerase-dependent extension. This provides a double-stranded DNA molecule for each detected protein, providing a unique barcode for high-sensitivity, high-specificity readout. The well-established Olink Target 96-panels use qPCR for the readout step, but marrying our elegant PEA technology with NGS for readout in Olink Explore provides several advantages:

  • Simultaneous analysis of 384 protein biomarkers
  • Use just 1 µL of biological sample
  • All assays subject to Olink’s strict technical validation and quality control procedures.
  • NGS readout
  • Higher throughput compared to our Olink Target 96 & 48 products
  • Similar accuracy and precision compared to our standard Target 96-plex and 48-plex products with qPCR readout
  • This high level of multiplexing is achieved without any compromise on data quality, thanks to our proprietary PEA technology