Olink® Explore 1536 by Olink Proteomics

Manufacturer Olink Proteomics
  |  1 reviews

Explore the low-abundant plasma proteome! Measure 1,536 proteins with minimal sample volume. Unparalleled specificity & sensitivity of PEA technology. Readout on NGS.

Olink® Explore 1536 by Olink Proteomics product image
Olink® Explore 1536
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Average Rating: 5.0
1 Scientist has reviewed this product

5 out of 5
Ease of use
5 out of 5
After sales service
5 out of 5
Value for money

  • Status:

  • Member since: 2021

  • Organization: VUMC

  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Incredibly innovative PEA technology! Amazing results.
Rating: 5.0

  • Application Area: Biomarker identification

"This product used state of the art technology to allow one drop of blood, less than 3 microliter, to provide information on the protein assays being measured. This allows for incredible insight into real-time human biology to help facilitate the development of more effective and targeted therapies. This in turn allows scientists/researchers to create new drugs while simultaneously continuing with clinical research/basic life science research for possible large-scale discoveries that will address the low abundant plasma proteome. "

Review date: 08 Apr 2021 | Olink® Explore 1536

Olink® Explore 1536 is a high-multiplex, high-throughput protein biomarker platform that uses Proximity Extension Assay (PEA) technology coupled to an innovative new readout methodology based on Next Generation Sequencing (NGS) using the Illumina® NovaSeq instrument.

PEA uses matched pairs of antibodies (Abs) attached to unique DNA oligonucleotides. When the correct pair simultaneously binds to a target protein, their DNA oligonucleotides hybridize and serve as a unique template for DNA polymerase-dependent extension. This provides a double-stranded DNA molecule for each detected protein, providing a unique barcode for high-sensitivity, high-specificity readout. The well-established Olink Target 96-panels use qPCR for the readout step, but marrying our elegant PEA technology with NGS for readout in Olink Explore provides several advantages:

  • 4-fold increase in multiplexing (from 96-plex to 384-plex)
  • 16-fold increase in the number of assays per run (from 96 to 1536)
  • 6.5-fold increase in throughput