DynaPro™ NanoStar™ II Dynamic Light Scattering Detector
Traditional dynamic light scattering, just better.
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It gives an answer in a very short time with small amounts of samples.
characterize protein sizes
It is simple to use, doesn't require a lot of sample. It gives results in a very short time.
Review Date: 27 Mar 2023 | Waters
Reliable data set.
Analyze the size and PDI of nanoparticles in colloidal state
As a bionanoengineer, I prepare a wide range of polypeptide based nanostructures for their biomedical applications. I have used another machine also for size measurement but this equipment is very sensitive as it can detect very minute levels of polydispersity in the sample which makes it a good equipment for size measurements.
Review Date: 20 Jul 2021 | Waters
Easy to use. Excellent service.
Analyze protein fiber formation and molecular weights
The instrument is very easy to set up and use. The credits from instrument purchase for attending lighting school is really helpful to master measurements.
Review Date: 27 May 2020 | Waters
Great product, fantastic service, amazing company
analyze crystallographic samples
The machine is excellent for sample characterization and intermolecular interaction assays (we work on RNA and protein interactions). The service engineers and Wyatt corporate have been outstanding and have bent over backwards to help our newly established laboratory with software, hardware, and user issues.
Review Date: 5 Jan 2017 | Waters
I would recommend this instrument as must have for full protein characterization
protein characterization
We are using this instrument to characterize our protein product. It is an essential tool for analytical and formulation to make decision on the go/no go project
Review Date: 23 Dec 2016 | Waters
Great and simple result giving interface
Protein analysis prior to crystallization
Great instrument giving clear results in short time. Temp controlling makes it easy to estimate temp for crystallization and potential protein aggregation. Kd analysis helps to modify ionic strength of the buffers. Connection easy to set up to computer in case your computer crashes. Wyatt staff very helpful in troubleshooting and analysis of results. After sale care is very good. You will not be left alone after warranty expires.
Review Date: 22 Dec 2016 | Waters
Very user friendly, high-throughput size measurements
Measure the size and temperature stability of nanoparticles
Very easy to use, you just enter a few values and make a spreadsheet with sample IDs, then press 'Go'. When you come back you have a plate full of data.
Review Date: 20 Dec 2016 | Waters
My core lab is unthinkable without Wyatt LS instruments!
Analyze variety of protein and peptide solutions and nanoparticles
I am a Wyatt products customer since 1999, and all of them I had were of top quality
Review Date: 29 Jun 2016 | Waters
Unique cuvette-based DLS
The DynaPro NanoStar II is a unique cuvette-based DLS instrument used for the analysis of proteins, gene therapy vectors, viruses and virus-like particles, promiscuous inhibitors, micelles, liposomes, lipid and metallic nanoparticles, and more. To accommodate scarce and precious samples, specially designed quartz cuvettes afford robust, accurate measurements with as little as 2 µL of solution, while our proprietary disposable cuvettes provide comparable sensitivity with as little as 4 µL!
Walk-up operation with DYNAMICS Touch™
The NanoStar is the only DLS instrument to provide a fully integrated, walk-up measurement experience. No need to boot up your lab PC, launch the DLS software, connect to the instrument and worry about where your data files are stored. DYNAMICS Touch is an intuitive—yet capable—DLS measurement app that resides right on the NanoStar. Via the full-size touch screen display, DYNAMICS Touch guides you through the entire setup and measurement process. It tells you if the data quality is sufficient for confidence in the results, and displays them instantly. Data files and concise PDF reports can be stored on the instrument, transferred via the network or downloaded to a flash drive. You can even send the report to your phone!
Full-featured analyses with DYNAMICS™
DYNAMICS is our powerful PC-based, comprehensive software package for collecting, analyzing, and reporting batch dynamic and static light scattering data. It performs advanced analyses and compares multiple data files to identify trends and statistics. DYNAMICS can control the NanoStar and acquire data directly, or read in DYNAMICS Touch data files.
DYNAMICS is offered with a 21 CFR Part 11 compliant Security Pack option, enabling the use of the DynaPro NanoStar in a GMP environment for quality control or at-line process monitoring.
Size and beyond
Coupled with the versatile and user-friendly DYNAMICS ™ software and DYNAMICS Touch ™ on-board app, the NanoStar may be utilized to measure not just size, size distributions, particle concentration and weight-average molar mass, but also solution properties relevant to sample stability: the second virial coefficient (A2 or B22), the diffusion interaction parameter (kD), turbidity or opalescence and the temperature of protein melting or aggregation onset (Tm, Tonset).
Cuvette, and yet...
... still another feature unique to the NanoStar: the optical fiber pickup may be coupled to any of Wyatt's on-line MALS detectors - the DAWN ™ or miniDAWN ™ - to add on-line DLS measurements in the same detection volume as SEC-MALS or FFF-MALS measurements.
Combining numerous benefits, the NanoStar is an unparalleled cuvette-based DLS detector. For higher productivity, consider the DynaPro™ ™ Plate Reader, the only commercially available DLS plate reader measuring in situ for high-throughput screening of thousands of conditions per day in industry-standard microwell plates.
Key features
- DYNAMICS Touch on-board app for walk-up operation
- Rh from 0.2 nm - 1000 nm
- Temperature from -10 °C to +120 °C
- Molecular weight from 300 Da to 1 MDa
- Turbidity from 1 to 80 NTU
- Separate, optimized SLS and DLS detection channels
- Auto-attenuation over five orders of magnitude
Versatile, high-quality options
Make measurements in super-high-quality quartz cuvettes with as little as 2 µL of sample, aqueous or organic solvents, over the entire, extended temperature range. This cuvette incorporates a solvent reservoir to prevent sample evaporation over high-temperature or extended analyses.
Our proprietary disposable cuvettes nearly match the optical quality of quartz yet require only 4 µL of sample, aqueous or select polar solvents. For convenience, larger-volume quartz and disposable cuvettes are also available.
A biopharmaceutical workflow powered by Wyatt Technology
Reliable biophysical characterization is a cornerstone of biologics development, playing a critical role at every stage – from selecting promising drug candidates to optimizing formulations and ensuring consistent manufacturing processes. Explore a comprehensive guide on how to deliver biopharmaceutical solutions, beginning with light scattering technology.
Particle size analysis by DLS for optimization of protein complexes for measurement by small-angle neutron scattering
Explore how dynamic light scattering (DLS) can be used to ensure monodispersity in protein samples for small-angle neutron scattering (SANS) studies. Discover how researchers using the DynaPro™ Plate Reader, detected protein aggregation that was undetectable by SDS-PAGE and UV spectroscopy. This method enhances sample quality assessment, ensuring reliable SANS measurements for studying Type I bacterial restriction-modification systems.
Characterization of AAV-based viral vectors by DynaPro DLS/SLS instruments
In this application note, Wyatt Technology explores the utilization of the DynaPro Plate Reader and DynaPro NanoStar instruments for the quantification of three quality attributes (QAs) of AAV drug products: aggregate content, thermal stability, and total viral particle concentration. These two technologies, which combine dynamic light scattering (DLS) and static light scattering (SLS) respectively, represent low-volume, quick-screening tools for quantifying AAV quality attributes.
Influence of heating rates on the thermostability characterization of antibodies by DLS and SLS
In this application note, the DynaPro® NanoStar® was used to study the impact of ramp rate on the apparent thermostability of trastuzumab (Her-ceptin), a commercially available mAb applied in the treatment of breast cancer. This study examined the effects of heating rate on the measured value of Tonset.
pH effects on stability and homogeneity of a protein complex analyzed by DLS
In this application note, the Wyatt DynaPro® dynamic light scattering (DLS) system was used to characterize the homogeneity and stability of heterodimeric protein complex (HPC) under various buffer conditions.
Screening developability and pre-formulation of biotherapeutics with high-throughput dynamic light scattering
As the pharmaceutical industry targets increasingly complex biologic candidates, automated formulation and analytical workflows play an important role in streamlining the development process. Explore the technology that powers automated high-throughput dynamic light scattering (HT–DLS) and its practical applications in candidate and formulation selection. Capable of performing 96 runs in under 45 minutes and 384 wells in 1.5–2 hours, with completely unattended operation, discover how high-performance HT–DLS accelerates analysis time, reduces the need for expert operator supervision, and improves confidence in data quality.
Organic-phase encapsulation in protein-based nanocapsules studied by DLS
In this application note, Wyatt Technology utilizes dynamic light scattering (DLS) and the DynaPro NanoStar DLS/SLS instrument to investigate protein-based nanocapsule formulation and dispersion properties based on particle size.
