Corning® Cholyl-Lysyl-Fluorescein (CLF), 1 mg by Corning Life Sciences

Manufacturer Corning Life Sciences  |   Model: 451041  |  Available in North America, Western Europe, Asia, Eastern Europe, Middle East, Africa
A fluorescein-labeled bile acid with a biological behavior that closely resembles that of naturally occurring cholyl glycine. CLF is mainly secreted into bile canaliculi by Bile Salt Efflux Pump (BSEP).Corning® Gentest™ CLF is suitable for studying the inhibition of bile acid efflux transporters, which is one mechanism involved in drug-induced cholestasis. The potential for a compound to cause cholestasis can be investigated in vitro by measuring the intensity of CLF accumulated in bile canalicu... Read more


Corning® Cholyl-Lysyl-Fluorescein (CLF), 1 mg by Corning Life Sciences product image
Corning® Cholyl-Lysyl-Fluorescein (CLF), 1 mg
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A fluorescein-labeled bile acid with a biological behavior that closely resembles that of naturally occurring cholyl glycine. CLF is mainly secreted into bile canaliculi by Bile Salt Efflux Pump (BSEP).

Corning® Gentest™ CLF is suitable for studying the inhibition of bile acid efflux transporters, which is one mechanism involved in drug-induced cholestasis. The potential for a compound to cause cholestasis can be investigated in vitro by measuring the intensity of CLF accumulated in bile canaliculi of hepatocyte cultures using fluorescence microscopy.

Advantages:

  • Easy identification and quantitation of bile canaliculi in hepatocyte cultures
  • Ability to measure inhibition to Bile Salt Efflux Pump (BSEP)
  • Can be multiplexed with other fluorescent microscopy-based toxicity assays
  • Ready to use – simply dissolve in culture media
  • CAS Number: N/A

  • Molecular Formula: C₅₁H₆₃N₃O₁₁S
  • Formula Weight: 926.13
  • Product Overview

    Corning® Cholyl-Lysyl-Fluorescein (CLF), 1 mg by Corning Life Sciences product image

    Corning® Cholyl-Lysyl-Fluorescein (CLF), 1 mg

    Manufacturer Corning Life Sciences  |  Available in North America, Western Europe, Asia, Eastern Europe, Middle East, Africa

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