Status:
ReviewerMember since: 2019
Organization: Genera D.d.
Very reliable instrument.
Application Area: Testing pharmaceutical products
"I use it with Chromeleon CDS. Works with no problem, it's reliable, service support is excellent."
Status:
ReviewerMember since: 2020
Organization: Eurofins WEJ Contaminants
Stable routine system.
Application Area:Food contaminants analysis
"Works stably in high-throughput 24/7 routine analysis. Only the thermostat in the autosampler has caused any problems - this had to be fixed twice."
Status:
ReviewerMember since: 2020
Organization: Swedish Matek
The service after purchase is the best in the industry.
Application Area:UHPLC
"The new 1290 UHPLC by Agilent provides accurate efficient results. The instrument is very robust and the service after purchase is the best in the industry."
Status:
ReviewerMember since: 2020
Organization: Novartis
Time and cost effective.
Application Area:Pharmaceuticals
"We get clear resolution within the lowest possible run times on this system. Results are accurate."
Status:
ReviewerMember since: 2020
Organization: Cipla
Very user friendly.
Application Area:UHPLC
"Helpful for high pressure analysis, and gives accurate results and functions smoothly."
Status:
ReviewerMember since: 2020
Organization: Thor Specialities
Modular system that helps to provide solutions for multiple applications.
Application Area:Bioside testing
"Modular system that helps to provide solutions for multiple applications. High volume sample compartment helps to expedite sample throughput for large sample batches."
Status:
ReviewerMember since: 2020
Organization: Swedish Match
Chromatography is very reproducible.
Application Area:LC analysis of tobacco
"Instrument is working well after almost constant use 5-6 days a week throughout the past year. Consumables are easily changed and chromatography is very reproducible."
Status:
ReviewerMember since: 2019
Organization: Galephar M/F
High performance for routine QC pharmaceutical analysis.
Application Area:Pharmaceuticals - small molecules
"The 1290 Infinity II series from Agilent Technologies offers a good balance between quality of results and routine ease of use. Complex seperations could be achivied thanks to the optimized LC modules."
Status:
ReviewerMember since: 2020
Organization: GLAUKOS
Instrument with exceptional reliability and robustness.
Application Area:R&D
"Best instrument for better chromatographic resolution, higher peak capacity for challenging separations and significantly better usability."
Status:
ReviewerMember since: 2018
Organization: AbbVie
Overall a great product.
Application Area:UHPLC method screening
"High performance system that is very easy to use, reliable and reproducible. Pump great for 1300 bar pressure and column compartment and detector work great. Autosampler thermostat is hit or miss. Design is rather compact but overall a great product."
Status:
ReviewerMember since: 2019
Organization: Alfasigma spa
Good product.
Application Area:Release finish products
"Instrument performs very well. Robust and precise. No maintenance required before or after assistance. The data is always reproducible and accurate."
Status:
ReviewerMember since: 2019
Organization: AIJU
The best results, an valuable instrument!
Application Area:Analytical Chemistry
"Agilent 1290 Infinity II has one of the easier learning curve because has very intuitive softwawre and the care service is very effective."
Status:
ReviewerMember since: 2015
Organization: Alkaloid AD
Great results.
Application Area:Small molecules
"We've upgraded Infinity systems with column and solvent selection valves, and we are very satisfied with the performance of the instrument. The only thing that is a little bit annoying is the manipulation of the column installation."
Status:
Advanced ReviewerMember since: 2019
Organization: SIA PharmIdea
Agilent HPLC is part of my family!
Application Area:Pharma industry
"Good equipment for effective analysis! Useful in method validation and for routine work life."
Status:
Advanced ReviewerMember since: 2018
Organization: IDF Inc.
Excellent for food and food safety analysis.
Application Area:Food analysis/food safety
"The 1290 LC with 6460 MS/MS produces excellent chromatography with MS/MS detection at low sensitivity and reproducible results. Easy to take care of an clean the MS/MS. Very robust MS/MS."
Status:
ReviewerMember since: 2016
Organization: AbbVie
This product is very easy to use.
Application Area:R&D and sample anlaysis
"This product is very easy to use. The built-in software can handle the sample analysis results efficiently and effectively."
Status:
Advanced ReviewerMember since: 2015
Organization: CONTINUUS Pharmaceuticals
Very good for general analytical applications. Good value for money.
Application Area:Analysis of different compounds by HPLC
"In my experience, the binary pump in the 1290 is one of the best in the market, it is capable of delivering very high flow rates with very little pulsing, as measured by the baseline noise. The instrument is compatible with several detectors, UV/Vis, DAD, MS, RI, fluorescence etc. [I have mine set up with a DAD and ES-MS in tandem]. The Chemstation software package is very user-friendly and faster to learn than other software systems. And it is much more affordable than its Waters and Thermo counterparts."
Status:
ReviewerMember since: 2016
Organization: National Agriculture research council
Good instrument which gives repeatable and reproducible results
Application Area:Pesticide residue analysis in food and feed
"Instrument is ideal with user friendly software for trace analysis of multipesticide residue in different environmental matrices. it is easily compatible with DaD and MS/MS. As it has single pump which makes it's results reproducible."
Status:
ReviewerMember since: 2018
Organization: IITB
Good working with it. Nice operation.
Application Area:Protein separation
"Good product. Yes, I would like to recommend it others."
Status:
ReviewerMember since: 2008
Organization: pfizer
This is much more rugged than previous UPLC/ UHPLC systems. Plus easier to work on.
Application Area:Bioconjugation analytics
"I ordered it with the same tubing that we use for our 1260s. It has had no downside, it can do anything the 1260 can (with more precise gradient control) and hasn't clogged. It has even survived getting pumped dry twice."
Status:
ReviewerMember since: 2017
Organization: AkzoNobel
Good and reliable instrument
Application Area:Performance test
"Easy to use instrument. Gives very high performance when switching to micro cell and capillaries."
Status:
ReviewerMember since: 2017
Organization: Charles university
We are convinced that it is one of the best solution for uhplc analysis today
Application Area:Pharmaceuticals
"Good system for fast and robust analysis. Best sensitivity when coupled to Single Quad mass detector. Very low dead volume that allows working on fast gradient mode. We are users for 1 year, we meet very few problems with it!"
Status:
ReviewerMember since: 2006
Organization: The Scotts-Miracle Gro Co
Great instrument, I like the sensitivity and the limited dead volumes.
Application Area:pesticide analysis
"This is another high quality instrument from Agilent. The drawback is the connection for the front end of the column. It is very fragile and easy to break. The replacement is expensive."
Status:
ReviewerMember since: 2016
Organization: Pfenex
Works great for RP-HPLC, but...
Application Area:SE-HPLC of Biologics
"As a long time Agilent user, I want to contribute a word of caution to those interested in using Agilent UHPLCs for salt-containing mobile phases. Agilent customer service (via phone) was surprised that the installation engineer said it was OK to run salts on the instrument. The small volumes cause the instrument to need a water flush immediately after every run, which is tough in our lab. We now have all UHPLC systems dedicated to RP-HPLC, which works VERY well on these instruments. It is also nice to have the purging integrated into the software, enabling us to fully control the instrument from our remote desktops outside of the lab (think COFFEE!)."
Manufacturer's ResponseThank you indeed for the feedback – it is great to hear you are having a good experience with Reverse Phase experiments on the 1290 Infinity II system. In regards to mobile phases with a high salt content, we do have users around the world running phosphate and other buffers routinely. We at Agilent also run similar types of experiments with robust and reliable results. One approach we have been successful with is to work with users to improve uptime by reducing the concentration of the salts while still maintaining sufficient buffering capacity; one possibility is to work with your local Agilent representatives or the phone support team to see if this is an option for your methods. Thank you very much for your feedback and for your purchase. Please don’t hesitate to contact Agilent if we might be of assistance with this or any other issue.
Status:
ReviewerMember since: 2016
Organization: Noramco
Dependable!
Application Area:Method Development and Analysis of APIs
"Love the Agilent 1290! This instrument works well for HPLC and UHPLC platforms. Easy to transfer methods from a Waters UHPLC to this instrument."
Status:
ReviewerMember since: 2016
Organization: Virchow Laboratories Ltd
Too fancy and less sturdy
Application Area:Fine chemicals and Active Pharma Ingredients
"We have been using the instrument for multiple products HPLC analysis. Column connecting ports are too fancy and delicate. Column changing will eat the life of the instrument and encounter with frequent service."
Status:
ReviewerMember since: 2016
Organization: Synergy
Superior system!
Application Area:Toxicology
"The UPLC-MS in our lab is twice as fast as the HPLC-MS. The chromatography also looks better and the instrument runs cleaner."
Status:
Advanced ReviewerMember since: 2008
Organization: -
Great instrument and flexible configuration option to suit different work flows.
Application Area:Analysr drug residues in blood samples
"I am using the Infinity II Series LC as a separation front end for my QTOF instrument in drug screening. The LC provides very robust performance and it is also easy to maintain. Built-in functionality such as the autosampler purging and washing helps reduce carryover which is a major concern for the type of work we do. We have another lab using the Infinity II LC, making use of the large volume injection capability to do small to medium scale purification work. This Infinity II LC series is indeed flexible and versatile, making it suitable for small and medium scale types of work flow."
Status:
Expert ReviewerMember since: 2015
Organization: Ajinomoto Althea
Amazing time saver!!
Application Area:Rapid reversed phase UPLC method development
"We use the 1290 Inifinity to convert exiting RP HPLC methods to UPLC. This has saved us immense amounts of development time and allowed us to return data to clients faster. Agilent continues to provide excellent after care support and OpenLab CDS software is familiar for all."
Status:
ReviewerMember since: 2014
Organization: Merck & Co, Inc.
Good; could be better
Application Area:mAbs (Biologics)
"Use it for analysis of mAbs with various HPLC based applications"
Status:
ReviewerMember since: 2016
Organization: Univ of Alberta
Tremendously improved the quality of the lab outputs
Application Area:Diagnostics
"Cut down run times by 4. Had an excellent after sale service. Compatible with other machines in the lab"
Status:
Advanced ReviewerMember since: 2008
Organization: -
Good LC system that I would recommend for any LC-MS and UHPLC users.
Application Area:Analyze drugs of abuse in urine samples.
"I use the 1290 Infinity LC as a separation front-end with a MS for the screening and detection of drugs of abuse in urine and plasma samples. Works great as a front end for LC-MS applications. Provides fast UHPLC separations that goes well with fast MRM detection that I am using. The LC is also easy to maintain and robust in performance. It lets me customize the system for both conventional analytical LC flow rates as well as fast LC flow rates. Very flexible. "
Status:
Advanced ReviewerMember since: 2014
Organization: Boehringer Ingelheim
Achieve great results with high efficiency
Application Area:pharmaceuticals R&D
"Very effective, high efficiency instrument, very robust with high precision. Cuts down analysis time and solvent usage."
Status:
ReviewerMember since: 2008
Organization: Quatest 2
Application Area:Food, Environment
"This equipment easy to use, we can apply for many fields in my lab with high quality results, high stability, good services after sales"
Status:
ReviewerMember since: 2014
Organization: Morton Grove Pharmaceuticals
Application Area:Small molecules and large molecules
"Transferred many products like Oral Solution, Suspension, IR Tablets, ER Tablets, DR Tablets and Injectable Impurity methods from HPLC to UPLC or UHPLC to shorter run time. I will be developing the future products methods using UPLC, UHPLC. "
Status:
ReviewerMember since: 2015
Organization: Colgate Palmolive
Application Area:Pharma, FMCG
"It is easy to use, and performance of the system is also excellent. Analysis results are also reliable, good value for money. Hardware is rugged."
Status:
ReviewerMember since: 2014
Organization: Swedish Match
"These LC systems are easy to use and very reliable. We were able to drastically cut analysis time. Agilent instruments are definite workhorse instruments. I would highly recommend. "
Status:
Advanced ReviewerMember since: 2014
Organization: XEPA-SOUL PATTINSON (M) SDN BHD
User-friendly and minimum maintenance required. After sales has been good
Application Area:For analysis of raw materials and finished drug products in pharmaceutical product development
"It is a very user-friendly instrument with minimum maintenance required. The after sales support of the seller too has been commendable."
Status:
ReviewerMember since: 2015
Organization: lab tecnical
Application Area:Metabolomics
"This system never fails. In the beginning, I found it was difficult to use but I was quickly able to manipulate it very well."
Status:
ReviewerMember since: 2004
Organization: HPLC Method Development
Excellent for method development, robust and good customer support
"Excellent for method development 8 columns, 12 solvents, no baseline noise practically Robust - we use it 4 .5 years without any spare part replacement. When call to support then immediately good and useful response. For cheaper system we spend more money to repair and buy spare parts. "
Status:
Expert ReviewerMember since: 2013
Organization: ONCODESIGN
Application Area:bioanalysis
"A good system but not as good as Acquity Waters UPLC or even Shimadzu Nexera. Carry over problems with some sticky compounds and needed to buy an extra module flexicube to get rid of the issue."
Status:
ReviewerMember since: 2013
Organization: University of Pecs
Application Area:Analysis of cavitand derivatives
"It is a very good and very useful instrument. However, the software Masshunter sometimes does not work well. I use this instrument for the analysis of cavitad derivatives."
Status:
ReviewerMember since: 2013
Organization: Dublin City University
Application Area:Pharmaceutical analysis
"Very easy to use, high sample throughput, online degassing and four lines for solvents. Easily made compatible with the software and very easy to use in combination with mass spectrometry. Not much after sales assistance provided so would be beneficial for new users to read a training manual prior to use but very simple to learn how to use through online manual with software. I would recommend to a colleague."
Status:
ReviewerMember since: 2013
Organization: University of Geneva
Application Area:BIOCHEMICAL
"It is easy to use, and well controlled with Analyst from ABSciex. It is easily connected to systems not sold by Agilent. The negative point would be that the Gameboy used to handle it manually for conditioning or column washing should be comprised in the package. The price of this Gameboy seems to be exaggerated to me."
Status:
ReviewerMember since: 2013
Organization: IVM.VU
Application Area:environmental analysis
"I have been working with this Agilent 1290 system for a year and I found it is really user friendly, thus I would strongly recommend the device."
Status:
ReviewerMember since: 2012
Organization: Genentech Inc.
Application Area:Pharmaceutical
"It is very easy to use. I am able to extract data at different wavelengths and to extract ion chromatographs. Also it suggests the structures if I enter the mass which I can correlate with my impurities. We have connected this system with 2D applications and it is very easily manageable and we are able to get the data without changing our methods and can still use buffers like phosphate."
Status:
Advanced ReviewerMember since: 2013
Organization: Ei, LLC
Application Area:Chromatography
"It is one of the highest quality pieces of equipment I have utilized in LC chromatographic analysis. This LC system is a rugged, reproducible, robust system and capable of producing high quality data. As an analytical chemist it is a refreshing experience to work with such sophisticated equipment."
Status:
ReviewerMember since: 2012
Organization: BASF
Application Area:Formulation development of pesticides
"The instrument is robust and rarely breaks down. It is efficient and allows a lot of samples to be analyzed in a short time. The instrument is easy for method transfer, the method can be easily transferred from other instruments (i.e. low pressure HPLC to UHPLC)."
The 1290 Infinity II LC System is an ultra-high performance LC that has market-leading sample capacity and is designed for the lowest dispersion for the most challenging ultra-HPLC experiments. The 1290 Infinity II LC system is designed to be both a HPLC and high-end UHPLC system in a single flow path, giving you robust and excellent performance no matter what application you are running while seamlessly integrating into your existing laboratory environment.
Features:
Manufacturer Agilent Technologies | Available Worldwide
4.3 / 5.0 | 57 reviews