Agilent 1290 Infinity II LC System by Agilent Technologies

"Works stably in high-throughput 24/7 routine analysis. Only the thermostat in the autosampler has caused any problems - this had to be fixed twice."

"The new 1290 UHPLC by Agilent provides accurate efficient results. The instrument is very robust and the service after purchase is the best in the industry."

"We get clear resolution within the lowest possible run times on this system. Results are accurate."

"Helpful for high pressure analysis, and gives accurate results and functions smoothly."

"Modular system that helps to provide solutions for multiple applications. High volume sample compartment helps to expedite sample throughput for large sample batches."

"Instrument is working well after almost constant use 5-6 days a week throughout the past year. Consumables are easily changed and chromatography is very reproducible."

"The 1290 Infinity II series from Agilent Technologies offers a good balance between quality of results and routine ease of use. Complex seperations could be achivied thanks to the optimized LC modules."

"Best instrument for better chromatographic resolution, higher peak capacity for challenging separations and significantly better usability."

"High performance system that is very easy to use, reliable and reproducible. Pump great for 1300 bar pressure and column compartment and detector work great. Autosampler thermostat is hit or miss. Design is rather compact but overall a great product."

"Instrument performs very well. Robust and precise. No maintenance required before or after assistance. The data is always reproducible and accurate."

"Agilent 1290 Infinity II has one of the easier learning curve because has very intuitive softwawre and the care service is very effective."

"We've upgraded Infinity systems with column and solvent selection valves, and we are very satisfied with the performance of the instrument. The only thing that is a little bit annoying is the manipulation of the column installation."

"Good equipment for effective analysis! Useful in method validation and for routine work life."

"Very easy to use."

"Easy to use."

"The 1290 LC with 6460 MS/MS produces excellent chromatography with MS/MS detection at low sensitivity and reproducible results. Easy to take care of an clean the MS/MS. Very robust MS/MS."

"This product is very easy to use. The built-in software can handle the sample analysis results efficiently and effectively."

"In my experience, the binary pump in the 1290 is one of the best in the market, it is capable of delivering very high flow rates with very little pulsing, as measured by the baseline noise. The instrument is compatible with several detectors, UV/Vis, DAD, MS, RI, fluorescence etc. [I have mine set up with a DAD and ES-MS in tandem]. The Chemstation software package is very user-friendly and faster to learn than other software systems. And it is much more affordable than its Waters and Thermo counterparts."

"Instrument is ideal with user friendly software for trace analysis of multipesticide residue in different environmental matrices. it is easily compatible with DaD and MS/MS. As it has single pump which makes it's results reproducible."

"Good product. Yes, I would like to recommend it others."

"I ordered it with the same tubing that we use for our 1260s. It has had no downside, it can do anything the 1260 can (with more precise gradient control) and hasn't clogged. It has even survived getting pumped dry twice."

"Easy to use instrument. Gives very high performance when switching to micro cell and capillaries."

"Good system for fast and robust analysis. Best sensitivity when coupled to Single Quad mass detector. Very low dead volume that allows working on fast gradient mode. We are users for 1 year, we meet very few problems with it!"

"This is another high quality instrument from Agilent. The drawback is the connection for the front end of the column. It is very fragile and easy to break. The replacement is expensive."

"As a long time Agilent user, I want to contribute a word of caution to those interested in using Agilent UHPLCs for salt-containing mobile phases. Agilent customer service (via phone) was surprised that the installation engineer said it was OK to run salts on the instrument. The small volumes cause the instrument to need a water flush immediately after every run, which is tough in our lab. We now have all UHPLC systems dedicated to RP-HPLC, which works VERY well on these instruments. It is also nice to have the purging integrated into the software, enabling us to fully control the instrument from our remote desktops outside of the lab (think COFFEE!)."

"Love the Agilent 1290! This instrument works well for HPLC and UHPLC platforms. Easy to transfer methods from a Waters UHPLC to this instrument."

"We have been using the instrument for multiple products HPLC analysis. Column connecting ports are too fancy and delicate. Column changing will eat the life of the instrument and encounter with frequent service."

"The UPLC-MS in our lab is twice as fast as the HPLC-MS. The chromatography also looks better and the instrument runs cleaner."

"I am using the Infinity II Series LC as a separation front end for my QTOF instrument in drug screening. The LC provides very robust performance and it is also easy to maintain. Built-in functionality such as the autosampler purging and washing helps reduce carryover which is a major concern for the type of work we do. We have another lab using the Infinity II LC, making use of the large volume injection capability to do small to medium scale purification work. This Infinity II LC series is indeed flexible and versatile, making it suitable for small and medium scale types of work flow."

"We use the 1290 Inifinity to convert exiting RP HPLC methods to UPLC. This has saved us immense amounts of development time and allowed us to return data to clients faster. Agilent continues to provide excellent after care support and OpenLab CDS software is familiar for all."

"Use it for analysis of mAbs with various HPLC based applications"

"Cut down run times by 4. Had an excellent after sale service. Compatible with other machines in the lab"

"I use the 1290 Infinity LC as a separation front-end with a MS for the screening and detection of drugs of abuse in urine and plasma samples. Works great as a front end for LC-MS applications. Provides fast UHPLC separations that goes well with fast MRM detection that I am using. The LC is also easy to maintain and robust in performance. It lets me customize the system for both conventional analytical LC flow rates as well as fast LC flow rates. Very flexible. "

"Very effective, high efficiency instrument, very robust with high precision. Cuts down analysis time and solvent usage."

"This equipment easy to use, we can apply for many fields in my lab with high quality results, high stability, good services after sales"

"Transferred many products like Oral Solution, Suspension, IR Tablets, ER Tablets, DR Tablets and Injectable Impurity methods from HPLC to UPLC or UHPLC to shorter run time. I will be developing the future products methods using UPLC, UHPLC. "

"The Agilent LC system is great and effective with high quality."

"It is easy to use, and performance of the system is also excellent. Analysis results are also reliable, good value for money. Hardware is rugged."

"These LC systems are easy to use and very reliable. We were able to drastically cut analysis time. Agilent instruments are definite workhorse instruments. I would highly recommend. "

"It is a very user-friendly instrument with minimum maintenance required. The after sales support of the seller too has been commendable."

"This system never fails. In the beginning, I found it was difficult to use but I was quickly able to manipulate it very well."

"Excellent for method development 8 columns, 12 solvents, no baseline noise practically Robust - we use it 4 .5 years without any spare part replacement. When call to support then immediately good and useful response. For cheaper system we spend more money to repair and buy spare parts. "

"A good system but not as good as Acquity Waters UPLC or even Shimadzu Nexera. Carry over problems with some sticky compounds and needed to buy an extra module flexicube to get rid of the issue."

"It is a very good and very useful instrument. However, the software Masshunter sometimes does not work well. I use this instrument for the analysis of cavitad derivatives."

"Very easy to use, high sample throughput, online degassing and four lines for solvents. Easily made compatible with the software and very easy to use in combination with mass spectrometry. Not much after sales assistance provided so would be beneficial for new users to read a training manual prior to use but very simple to learn how to use through online manual with software. I would recommend to a colleague."

"It is easy to use, and well controlled with Analyst from ABSciex. It is easily connected to systems not sold by Agilent. The negative point would be that the Gameboy used to handle it manually for conditioning or column washing should be comprised in the package. The price of this Gameboy seems to be exaggerated to me."

"I have been working with this Agilent 1290 system for a year and I found it is really user friendly, thus I would strongly recommend the device."

"It is very easy to use. I am able to extract data at different wavelengths and to extract ion chromatographs. Also it suggests the structures if I enter the mass which I can correlate with my impurities. We have connected this system with 2D applications and it is very easily manageable and we are able to get the data without changing our methods and can still use buffers like phosphate."

"It is one of the highest quality pieces of equipment I have utilized in LC chromatographic analysis. This LC system is a rugged, reproducible, robust system and capable of producing high quality data. As an analytical chemist it is a refreshing experience to work with such sophisticated equipment."

"The instrument is robust and rarely breaks down. It is efficient and allows a lot of samples to be analyzed in a short time. The instrument is easy for method transfer, the method can be easily transferred from other instruments (i.e. low pressure HPLC to UHPLC)."

"A nice UPLC, very robust."

"A good HPLC."

"A powerful instrument."

"Really powerful."

"A high pressure system giving reliable and precise results."

"Robust, reliable performance."