ACQUITY UPLC® I-Class PLUS System

This application note demonstrates the advantage of a lower hydrophobicity stationary phase that bears a charged surface potential, namely the CSH Phenyl-Hexyl stationary phase from Waters Corporation.

In this white paper, Waters Corporation discusses the future trends in the biopharmaceutical industry including multi attribute monitoring (MAM), biophysical analysis as a complement to analytical characterization, and the rise of mass detection as a foundational technology.

Oligonucleotide therapeutics have emerged in recent years as a powerful alternative to small molecule and protein therapeutics. Manufacturing and quality control of oligonucleotide therapeutics requires highly selective and sensitive LC-MS methods. The method often used for mass spectrometry-based oligonucleotide analysis has been reversed-phase chromatography employing a variety of ion-pairing reagents and modifiers in negative ESI-MS mode. Integrated LC-MS workflows for oligonucleotide analysis have been recently implemented on quadrupole and QTof LC-MS platforms.

In this application note, Waters discusses using the ACQUITY UPLC I-Class system for highly sensitive MS methods, without compromising on important factors such as sample throughput.

In this application note, Waters Corporation evaluates the performance of three high-pressure binary liquid chromatography (LC) systems using a generic peptide mapping method. This evaluation highlights the reproducibility of the ACQUITY UPLC I-Class PLUS System compared to methods from other vendors that utilize long, shallow gradients.

In this application note, a comparison was performed between Oasis PRiME HLB SPE, SLE and LLE in both plasma and urine matrices for bioanalysis and forensic toxicology. In plasma, 22 comonly analyzed pharmaceuticals, steroids, and drugs of abuse were extracted using the three aforementioned methods and the results were compared. In urine, 23 drugs of abuse representing opioids, stimulants, benzodiazepines, and synthetic cannabinoid metabolites were tested for forensic toxicology analysis.

Cyanobacteria produce secondary metabolites, some of which are toxic to higher order organisms, such as microcystins. Microcystins are highly soluble compounds that can induce severe hepatotoxicity; the risk to human health is a concern. This application note describes a method for the analysis of drinking and surface waters for 10 well known cyanotoxins - using liquid chromatography tandem mass spectrometry.

Beta-adrenergic receptor agonists are synthetic compounds that mimic some of the effects of naturally-occuring compounds by binding to beta-receptors on the surface of cells within the muscle, fat, and other tissues of animals. Some beta-agonists are used in human medicine for the treatment of conditions such as asthma, but they have also been used in livestock production to enhance growth and alter body composition.

Explore the analytical capabilities of Waters LC-MS/MS technology for analytes commonly used in the areas of endocrinology and therapeutic drug monitoring (TDM) work in the clinical laboratory.

Since its introduction in 2004, each addition to the Acquity family has continuously pushed forward to enable you to find faster, simpler and better ways to support the work that you do.

Watch this video to learn about The Imperial International Phenome Centre (IIPTC), which is part of the MRC-NIHR Phenome Centre. The Imperial IIPTC offers training in the techniques of both liquid-chromatography mass spectrometry (LC-MS) and nuclear magnetic resonance (NMR) spectroscopy in the field of metabonomics, metabolomics and metabolic profiling. The basics of LC-MS and NMR are covered, along with data analysis of large sample sets using statistical techniques such as PCA and O2-PLS.

In this video the ACQUITY UPLC I-Class, Xevo G2-XS QTof and UNIFI Scientific Information System brings the power and versatility of high resolution mass spectrometry to the routine forensic toxicology laboratory.

As a leading clinical LC-MS/MS solutions partner, Waters is a trusted provider of in vitro diagnostic medical devices, consumables, informatics, and support services for high performance LC-MS/MS systems. Learn how and why University Hospital of South Manchester has introduced Waters LC-MS/MS IVD instrumentation into their busy clinical laboratory.

At ASMS 2015, Dr John Langley, Associate Professor in Mass Spectrometry at the University of Southampton, discussed how he keeps his lab at the cutting edge of separation science, with help from the ACQUITY UHPLC and UPC2 systems from Waters. In this video, he explains why he made the change from HPLC to UHPLC and how Open Access analysis has revolutionized his research.

Personalized medicine is all about delivering the correct treatment for the right individual based on their genes and environment. Find out how the use of mass spectrometry and NMR spectroscopy enables an overview of hundreds of thousands of metabolites in a single analytical run covering a large number of physiological and metabolic processes.

Dr Matthew Lewis describes how the MRC-NIHR Phenome Centre investigates what makes people metabolically different. By analyzing large cohorts of patients and performing epidemiological studies, an insight into the understanding of human metabolism can be achieved. NMR and UPLC mass spectrometry are used with a combination of different chromatography methods to gain accurate analysis of small molecules in human samples.

Watch this video to see how the ACQUITY UPLC® I-Class System provides the most powerful solution to the most critical need in separation science today. Discover how the ACQUITY UPLC® I-Class System can successfully analyse compounds that are limited in amount or availability amid a complex matrix, more rapidly than ever before.

Scientists from Abu Dhabi’s RASID lab provide an insider’s look at the high-throughput wastewater analysis facility

Discover how to minimize the loss of metal-sensitive analytes and achieve fast analysis and high recovery of oligonucleotides

Kristen Burke from the California Department of Justice explains her department's cutting-edge LC/MS method for optimized analysis of routinely encountered drugs of abuse

Watch this on-demand webinar to learn how to perform untargeted/semi-targeted metabolomic studies to discover novel biomarkers by mass spectrometry

Experts Dr. Paula Hong and Jennifer Simeone review how each autosampler aliquots and delivers the sample and discuss their differences

As the number of analytical monitoring tests for biopharmaceuticals skyrockets, Waters builds intelligence into a fit-for-purpose system

Learn how a lab in the US is using enhanced chromatography and spectrometry techniques to analyze cellular metabolites in urine linked with future cancer risks

Read the highlights from our recent webinar on chromatography for biopharma

How the Acquity UPLC system can save you time, money and solvent consumption