TSQ Altis™ MD Mass Spectrometer
Develop in vitro diagnostic tests for demanding quantitative analyses leveraging the enhanced sensitivity and remarkable speed and robustness of the Thermo Scientific™ TSQ Altis™ MD Series Mass Spectrometer. The TSQ Altis MD Series mass spectrometer, a Class I medical device, offers superb analytical performance and features the maximum usability, sensitivity and robustness required for laboratory developed tests (LDTs) from c…
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Develop in vitro diagnostic tests for demanding quantitative analyses leveraging the enhanced sensitivity and remarkable speed and robustness of the Thermo Scientific™ TSQ Altis™ MD Series Mass Spectrometer. The TSQ Altis MD Series mass spectrometer, a Class I medical device, offers superb analytical performance and features the maximum usability, sensitivity and robustness required for laboratory developed tests (LDTs) from clinical diagnostic laboratories. With superb analytical performance, this platform features maximum usability, sensitivity, and robustness.
- Powered by Thermo Scientific™ TraceFinder™ LDT Software, which provides a workflow-oriented approach to robust, reliable, high-throughput quantitation
- Ultimate quantitative performance leveraging enhanced Thermo Scientific™ Active Ion Management (AIM+) technology
- QR5 segmented hyperbolic-surface quadrupoles deliver best-in-class sensitivity, consistency, and reproducibility
- Fast, selected-reaction monitoring enables robust quantitation of more compounds faster
- Automated compound optimization and intuitive instrument interface
- Optional bi-directional LIS connection available with B-link
Intended Use
The TSQ Altis MD Series mass spectrometer is intended to identify and quantify inorganic and organic compound in human specimens. For in vitro diagnostic use only by trained, qualified laboratory personnel. For in vitro diagnostic applications only.
Indications for use
The TSQ Altis MD Series mass spectrometer will be used by clinical diagnostic laboratories as a component of a laboratory developed test (LDT) method or workflow.
Contraindications of Use
For in vitro diagnostic applications only. The TSQ Altis MD Series mass spectrometer is to be operated only with hardware or software labeled for in vitro diagnostic use.
Limitations of Use
The TSQ Altis MD triple-stage quadrupole mass spectrometer has been evaluated and determined to be compatible with the following Thermo Scientific instruments:
- Thermo Scientific™ Vanquish™ MD Single Channel HPLC
- Thermo Scientific™ Prelude™ MD Dual Channel HPLC
- Thermo Scientific™ Prelude™ LX-4 MD Four Channel HPLC
As a component of an LDT method or workflow, validation of the LDT method or workflow is the responsibility of the clinical laboratory.
Direct analysis of selected PFAS in ground, surface, and waste water by LC-MS/MS
There is documented evidence that exposure to per- and polyfluoroalkyl substances (PFAS) can lead to adverse health outcomes in humans, with studies showing that perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) can cause reproductive and developmental, liver and kidney, and immunological effects in laboratory animals. Thermo Fisher Scientific describes a direct analysis method for the determination of a list of 24 PFAS in a wide variety of non-drinking water matrices. The data was used for the validation of a new method, EPA 8327, for a wide variety of water matrices as part of an interlaboratory study sponsored by the EPA Office of Water.
Quantitation of 22 fentanyl analog compounds with a TSQ Altis MD mass spectrometer
The rise in not only the abuse of prescription drugs, but also synthetic opioids, has created a demand for toxicology labs to test for fentanyl-related compounds, including fentanyl. In this application note from Thermo Fisher Scientific, explore a method for quantitation of the Traceable Opioid Material™ (TOM) kit compounds in urine that includes sample preparation by supported liquid extraction (SLE) and quantitation by selected reaction monitoring (SRM) on a Thermo Scientific™ TSQ Altis™ MD Triple Quadrupole mass spectrometer.
A quick and robust mass spectrometry-based method for the detection of SARS-CoV-2
In this application note, Thermo Fisher Scientific presents a reliable mass spectrometry-based method for detecting SARS-CoV-2 peptides, crucial biomarkers for active COVID-19 infection. The study demonstrates the detection of six peptides from recombinant protein samples spiked onto nasopharyngeal swabs or saliva, placed in viral transport media, and enzymatically digested. The results show sub/low-femtomole on-column detection and quantification limits for each peptide, showcasing the potential of utilizing the TSQ Altis™ MD mass spectrometer for COVID-19 testing.
Comparison of ionization types and precursor ions for quantitative analysis of 25-hydroxyvitamin D on a TSQ Altis MD mass spectrometer
In this application note, Thermo Fisher Scientific compares variations of an analytical method for detecting and quantifying 25-hydroxyvitamin D2 and D3 using a Thermo Scientific™ TSQ Altis™ MD mass spectrometer. The note emphasizes the essential role of vitamin D in various biological functions, including promoting the absorption of calcium and supporting healthy bone growth. It highlights that vitamin D deficiency can lead to weakened bones, with manifestations like rickets in children and osteomalacia in adults, causing soft and malformed bones, reduced growth, and muscle weakness.
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