TSKgel UP-SW Series UHP-SEC Columns
TSKgel UP-SW Series offers highest resolution based on established SEC technology.
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TSKgel UP-SW columns packed with 2 µm silica based particles are the latest addition to the popular TSKgel SW series. These silica-based UHPLC/HPLC columns are based on the same proven proprietary surface technology of the renowned TSKgel SW series. Pore sizes and surface modifications are similar to the renowned TSKgel SWXL series which facilitates method transfer from conventional gel filtration to UHPLC.
TSKgel UP-SW Series Features:
- TSKgel UP-SW3000 for high resolution between aggregates, monomer, and fragments
- TSKgel UP-SW2000 for SEC of large peptides, small proteins or mAb fragments
- Consistent lot-to-lot reproducibility and long column lifetime
- Ease of method transfer from HPLC to UHPLC
Analysis of oligonucleotides by SEC-MALS
Therapeutic oligonucleotides are produced through a synthetic solid-phase chemical synthesis, which often produces some heterogeneity regarding chain distribution. Monitoring of this distribution is a fundamental aspect of process and quality control, which is typically done by capillary gel electrophoresis (CGE) or anion exchange chromatography. Tosoh Bioscience demonstrates the ability of size exclusion chromatography (SEC) to discriminate oligonucleotides differing by one base in length. Using the TSKgel® UP-SW2000 size exclusion column, in combination with UHPLC and UHPLC-MALS systems, discover how this column is suitable for oligonucleotide analysis, combined with multi-angle light scattering detection.
(U)HPLC analysis of biomolecules
This compendium, from Tosoh Bioscience, compiles more than twenty application notes covering important aspects of biopharmaceutical analysis such as protein aggregation, charge isoforms and glycosylation as well as determination of drug-to-antibody ratio of antibody-drug-conjugates. The last section of the notebook provides tips and tricks to improve chromatographic separation of biomolecules.
Tosoh Bioscience celebrates 50th anniversary of the TSKgel column brand
TSKgel S-type columns have paved the way for an entire suite of columns in nearly every mode of liquid chromatography
