Products & ReviewDrug Discovery & Development
TARGATT™ iPSCs Kits
Applied StemCellWorldwide
Build tomorrow’s cell therapies and cell-based disease models using TARGATT™ Human Induced Pluripotent Stem Cell (hiPSC) Kits. With the ability to efficiently and site-specifically insert 20+ kb of DNA (more with nested reactions), TARGATT™ hiPSC technology enables expression of large proteins and multi-protein complexes in hiPSC-derived human cell lines.
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Description
- Insert genes with confidence—with TARGATT™ technology you can achieve site-specific, single-copy insertion of 20+ kb at the reliable H11 safe-harbor locus
- Build complex constructs—20+ kb knock-in capability means you can engineer and evaluate large therapeutic payloads, synthetic circuits, and immune-modifying elements
- Develop cell lines fast—with efficient, site-specific insertion at the H11 locus, you can be confident in reliable gene expression that is consistent from clone to clone, speeding you to your next step
- Streamline commercialization—straightforward licensing with clear freedom-to-operate
Find a kit for your needs
These kits include a TARGATT™ landing pad in hiPSCs reprogrammed from male CD34+ cord blood cells
- Hypoimunogenic TARGATT™ hiPSC Knock-in Kit (Cat.# AST-9650)—B2M/CIITA double knock-out eliminates expression of HLA Class I and II molecules to avoid recognition by CD8+ and CD4+ T cells (GMP version coming in 2026)
- GMP-Matching RUO TARGATT™ hiPSC Knock-in Kit (Cat.# AST-9450)
- GMP TARGATT™ hiPSC Knock-in Kit (Cat.# AST-9480)
This kit includes a TARGATT™ landing pad in hiPSCs reprogrammed from female fibroblasts
- TARGATT™ Female hiPSC Knock-in Kit (Cat.# AST-1602)
