SiriusT3 Automated platform for the determination of Physicochemical Properties
Sirius T3 measures pKa, log P, and the solubility of ionizable drugs and small molecules using sub-milligram quantities of samples.
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The Sirius T3 is ideal for early-stage compound screening, PhysChem characterization, and pre-formulation studies, running complicated assays with automated reagent delivery, stirring, spectra collection, pH measurement, and temperature control.
Benefits:
- Elucidate drug potential
- Globally renowned as the gold standard technique for determination of pKa, logP/D and solubility of ionizable compounds.
- Rich insights to discovery scientists allowing them to make accurate and assured decisions about their drug candidates.
- Determine pKa values using two techniques: spectrometric (for UV-active compounds) and potentiometric (for non-UV active compounds). With high throughput automated screening capabilities, SiriusT3 can complete up to 80 assays a day.
- Determine the intrinsic solubility of the different forms (crystalline and amorphous) for polymorphs compounds using the Pion’s CheqSol technique.
Features:
- Requiring only sub-milligram sample quantities in most cases, the SiriusT3 can complete the analysis in less than 6 minutes per titration using the high throughput pKa screening.
- Determine pKa values using two techniques: spectrometric (for UV-active compounds) and potentiometric (for non-UV active compounds). With high throughput automated screening capabilities, SiriusT3 can complete up to 80 assays a day.
- Measure log P/D as a function of pH in less than 2 hours using the potentiometric technique in place of traditional shake-flask methods. Determine kinetic and intrinsic solubility using Pion’s patented CheqSol technique within two hours.
- Use the CheqSol technique to provide intrinsic solubility as a function of pH and generate detailed information about the extent and duration of the supersaturated states.
Advancing oral drug development with in vitro dissolution and absorption tools
June 9, 2025 16:00 BST / 17:00 CEST / 11:00 EDT / 08:00 PDT
Effective absorption and therapeutic performance are essential to the success of oral small molecule drugs. In order to achieve this, understanding key biopharmaceutical properties such as solubility, dissolution, and membrane permeability are crucial for optimization as these factors can influence bioavailability and overall clinical efficacy.
Join Karl Box, Chief Scientific Officer at Pion Inc, as he explores innovative in vitro techniques that can help characterize key biopharmaceutical properties — enabling better decision-making from early discovery through to formulation optimization.
Designed for scientists and formulation teams, this exclusive webinar will highlight practical approaches to evaluating oral drug performance using dynamic dissolution and absorption models. Whether you are working on preclinical candidates or refining final dosage forms, gain insight into how real-time in vitro testing can be used to identify formulation risks early, troubleshoot challenges, and support a more efficient development process, to enhance the predictability and success of oral drug development.
Key learning objectives
- Understand how to apply small-scale and biorelevant dissolution testing to support formulation strategy.
- Explore tools and workflows for assessing supersaturation/precipitation and excipient selection.
- Gain insights into how in vitro data can guide risk assessment and improve developability profiling.
- Learn how to predict oral absorption (Fa%) and assign the BCS Class of your compound.
Who should attend?
- Pharmaceutical scientists involved in drug development and formulation.
- Preclinical development teams looking to improve biopharmaceutic assessments.
- Anyone interested in enhancing their understanding of oral absorption and developability assessment using in vitro methods.
- R&D professionals interested in in vivo predictive tools.
Certificate of attendance
If you attend the live webinar, you will automatically receive a certificate of attendance, including a learning outcomes summary, for continuing education purposes.
If you view the on-demand webinar, you can request a certificate of attendance by emailing editor@selectscience.net.
