ioGABAergic Neurons
Human iPSC-derived GABAergic neurons
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- Cryopreserved human iPSC-derived cells powered by opti-ox, that are ready for experiments in days
- Ideal for multi-cellular in vitro modelling studies of complex CNS biology
- >99% pure inhibitory neurons, which form functional neural networks with glutamatergic neurons and astrocytes
ioGABAergic Neurons are human induced pluripotent stem cell (iPSC)-derived GABAergic neurons, also known as inhibitory interneurons, and are deterministically programmed using opti-ox technology. Within 4 days post-revival, ioGABAergic Neurons form a highly pure (>99%), defined population that is ready for experimentation, expressing classical marker genes including GAD1, GAD2, VGAT, DLX1 and DLX2. These inhibitory neurons display spontaneous activity as demonstrated by calcium imaging. ioGABAergic Neurons are also suitable for co-culture and tri-culture studies with ioGlutamatergic Neurons and Astrocytes to gain insights into complex intercellular interactions.
ioGABAergic Neurons provide a highly pure, consistent, functional and easy to use human iPSC-based model for the study of neural circuits, and for neurological disease research and drug development.
Advancing rare disease drug discovery using consistent, defined human neurons
This case study describes how the To Cure A Rose Foundation used bit.bio’s ioGABAergic human neurons to accelerate preclinical drug discovery for an ultra‑rare neurodevelopmental disorder caused by mutations in HNRNPH2. Discover how by leveraging consistent, scalable, iPSC‑derived neuronal models, the team was able to rapidly screen antisense oligonucleotide (ASO) candidates and progress promising therapies toward clinical development.
