ioHepatocytes
Cryopreserved human iPSC-derived cells powered by opti-ox, that are ready for experiments in days. Ideal for hepatotoxicity screening, drug metabolism studies, and disease modeling. Consistent, functional hepatocytes for long-term 2D culture.
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Powered by opti-ox™ deterministic programming, ioHepatocytes deliver a scalable, highly consistent source of human iPSC-derived hepatocytes that eliminate donor variability.
ioHepatocytes display classic cobblestone morphology with distinctive nuclei and well-defined borders. They express key pan-hepatocyte markers, including ALB, HNF4A, ASGR1, CYP3A4, and present a transcriptomic signature similar to primary human hepatocytes (PHHs).
In 2D monolayer cultures, ioHepatocytes exhibit long-term functional viability exceeding 17 days, characterized by robust albumin secretion and active CYP450 enzymes.
Critically, the cells express key Phase I, II, and III drug metabolism genes. When challenged with known hepatotoxins, they successfully mirror the DILI response of primary human hepatocytes, offering an optimized, human-relevant platform for predictive toxicology, metabolic profiling, and disease modeling.
