Revident quadrupole time-of-flight LC/MS (LC/Q-TOF)
To stay competitive and adjust to changing industry requirements, you need evolved instrumentation with complete workflow solutions to meet current and future challenges. You must ensure that your lab can respond to emerging and unexpected contaminants with broader screening and retrospective analysis. The Agilent Revident LC/Q-TOF answers these challenges by maximizing time and productivity with sophisticated instrument inte…
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Fully compliant HRMS model for all Peptide and Oligo Characterization studies and E&L studies
Peptides characterization and Extractable & leachable Studies
This Revident QTOF offers a benefit over the previous model, the 6545XT, by providing a single, user-friendly processing software for all our peptide and oligonucleotide characterization studies, which is also 21CFR-compliant. The E&L library is enhanced with more compounds, and the processing software is updated to 21 CFR compliance. This provides more confidence in the reliability of the data generated for characterization studies.
Review Date: 1 Dec 2025 | Agilent Technologies
The Revident LC/Q-TOF embodies the next generation of quadrupole time-of-flight instruments featuring truly innovative (electronic) instrument architecture together with instrument intelligence, a novel, ultrafast detector, and an updated, robust calibrant delivery system. Excelling in routine screening, high resolution, accurate-mass quantitation, identification of unknowns, and high-throughput testing, the Revident Q-TOF LC/MS system is ideal for small molecule applications in food safety and environmental analysis, as well as metabolomics, pharmaceutical, and forensic analyses.
Innovative technologies that will increase productivity include Intelligent Reflex for maximized instrument uptime, scheduled tunes and calibration for optimal performance when you need it, and new acquisition software tailored to different user roles. All new features combined result in higher throughput, which increases the bottom-line financials for your lab.
Features:
- High resolution (Hi-Res) mass spectrometry screening can be used to increase measurement capabilities dramatically for analyses of samples with large numbers of suspects, including retrospective analysis using full mass spectra information
- Simultaneous routine screening and quantitation using data-independent acquisition modes enable sensitive detection and identification of contaminants that maintain performance at high acquisition rates
- Optimal instrument performance via scheduled tunes and calibration, early maintenance feedback, and instrument diagnostics increases your lab productivity
- Intelligent Reflex workflows include automatic reinjection for carryover, saturation, fast screening, suspect screening confirmation, and iterative MS/MS that allow the instrument to continuously acquire data while you focus on the results
- New and intuitive mass spectrometry acquisition software is aligned with the LC/TQ UI, and it is simplified and tailored to different lab roles from technician to lab manager and auditor
- Identification of unknowns is enhanced by a new software workflow for seamless batch processing and statistical analysis with subsequent identification of compounds derived from the significance analysis
- Innovative modular design including readbacks represents highly sophisticated and complete instrument diagnostics, with all relevant information constantly monitored, allowing for fast and reliable detection of the individual component’s status
- A completely new detector based on analog-to-digital conversion (ADC) generates mass peaks with high resolution and isotope fidelity, with the obtained peak symmetry maintaining high mass accuracy through different abundance levels
- New delivery system for calibrant and reference masses is pump-based and flow-controlled, permitting constant and reliable flow rates
Intelligent reflex targeted reinjection workflow for pesticide screening in food matrices
Robust and reliable screening methods for pesticide analysis in food matrices are a continuous point of challenge with the growing number of matrix samples, varying detection limits, and a continuously expanding list of emerging contaminants. Data-independent acquisition (DIA) methods allow users to simultaneously screen for targets of interest while also evaluating valuable information on unknown compounds. Agilent Technologies demonstrates a DIA methodology for the screening of pesticides in a complex matrix with the Agilent Revident Q-TOF LC/MS. Plus, discover how intelligent reflex automated targeted reinjection has been used for the acquisition of compounds screened as present or questionable.
Routine pesticide screening solution: Data independent acquisition with a new LC/Q-TOF and dedicated screening software
The requirement for robust and reliable screening methods for pesticides in food matrices continues to emerge as a point of challenge and necessity. The utilization of data independent acquisition (DIA) affords scientists the ability to screen for targets while also acquiring non-targeted fragment information, which could be used for retroactive analysis of emerging contaminants and future suspects. A high-resolution LC/Q-TOF (quadrupole time of flight) facilitates the DIA acquisition while aiding identification with extended dynamic range, stable accurate mass, isotopic fidelity, and acquisition speeds supporting specificity of fragment ions. Agilent Technologies presents a workflow for pesticide screening that includes QuEChERs sample preparation, the Agilent 1290 Infinity II LC, the new Revident LC/Q-TOF, and MassHunter Quantitative Analysis 12 Screener Tool for fast and routine pesticide analysis.
From data-independent acquisition (DIA) to targeted MS/MS: Automatic reinjection for additional confirmation in suspect screening
Multi-residue screening in food safety is challenged with an ever-growing list of regulated residues.To comply with SANTE guidelines for the simultaneous identification and quantitation of compounds, overlapping molecular ions and a specified number of fragments are required over the chromatographic peak. DIA workflows fulfill these requirements but can yield questionable results. In this poster, Agilent Technologies presents the concept of an intelligent reflex, where after the initial sample run in DIA mode (All Ions) the data is processed, and automatically appended to the running worklist to confirm questionable or identified residues via targeted MS/MS. Agilent Technologies demonstrates in this study that the Revident LC/Q-TOF is highly suitable for routine screening in food safety applications.
Revident quadrupole time-of-flight LC/MS system (LC/Q-TOF)
In this video, Agilent Technologies demonstrates the Revident LC/Q-TOF, a state-of-the-art quadrupole time-of-flight system incorporating integrated intelligent workflow solutions. This advanced system allows for swift and accurate identification and assessment of specific compounds. Explore the capabilities of this next-generation technology for practical laboratory applications.
The pivotal role of instrument intelligence in the future of mass spectrometry
Mass spectrometry has become a reliable technique used across many applications. Recent advances in instrument intelligence, such as predictive maintenance, are now providing mass spectrometry users with the ability to streamline laboratory processes, reduce human error, and increase data accuracy and consistency. In this video, Ken Suzuki, Vice President & General Manager, Mass Spectrometry Division, Agilent Technologies, discusses how the Agilent 6495D LC/TQ and the Agilent Revident LC/Q-TOF incorporate numerous intelligence features crucial for generating meaningful scientific insights and maximizing operation time and productivity.
This video was filmed at ASMS 2023.
Agilent Revident LC-Q-TOF
Staying credible and competitive means keeping up with current and future regulations and responding quickly to emerging contaminants. Failure to do so can result in excessive method development time, regulatory fines, and revenue loss from extra testing. In this video, Agilent introduces the new Revident LC/Q-TOF developed to overcome these challenges. With integrated intelligent workflow solutions, this next generation of quadrupole time-of-flight system lets you identify and quickly assess compounds in question. Get ready to be inspired by a smarter lab.
Targeted metabolomics and lipidomics workflows powered by intelligent mass spectrometry lead to greater biological insights
Omics expert, Professor Gary Patti, shares his thoughts on the current trends in metabolomics and discusses how multiple omics datasets can enhance our understanding of biology and disease
Revolutionize pesticide residue testing in food with intelligent LC/MS
The Agilent 6495 LC/TQ and Revident LC/Q-TOF LC/MS systems deliver maximum uptime, throughput, and insight to meet the ever-evolving demands of food testing
Agilent announces new mass spectrometry solutions at ASMS 2023
The new systems are designed to tackle challenging targeted analysis applications requiring the highest analytical sensitivity
