Resolvex i300

Sample extraction and purification are at the core of modern laboratory workflows, supporting vital fields like proteomics, genomics, and biopharmaceutical production. Automation is revolutionizing these processes by reducing human error, increasing throughput, and boosting lab efficiency.

The latest sample prep instruments integrate sample cleanup, evaporation, and resuspension into a single platform, making complex sample prep more efficient and scalable for everything from method development to large-scale purifications.

This eBook provides valuable resources and case studies to guide you through the latest automation technologies. Learn how Tecan’s cutting-edge lab instruments and automated workflow platforms can transform your lab’s efficiency and output.

Explore case studies such as:

• Semi-automated supercoiled plasmid DNA extraction
• Enhanced biomolecule cleanup in mass spectrometry
• Automated high-throughput plasma proteome sample preparation
• Simplified, automated sample preparation
• Automated on-column protein digestion and peptide desalting for high-throughput proteomics

Plasma proteomics plays a crucial role in studying human health and disease by providing a comprehensive view of an individual's physiological state. Mass spectrometry (MS) is utilized for proteome analysis due to its high sensitivity and specificity. In this application note, Tecan describes a study focused on implementing a simplified and automated sample preparation workflow for plasma proteomics using the ENRICH-iST technology on a Fluent® Automation Workstation with the Resolvex® i300 module. Automation of the ENRICH-iST process on the Fluent system streamlines the workflow from plasma samples to dried peptides, ensuring reproducibility and scalability for large cohort studies.

The detection of synthetic opioids including fentanyl in biological samples is crucial in clinical and forensic toxicology. Analysis techniques, such as liquid chromatography-tandem mass spectrometry (LC-MS/MS) enable multiplexed detection of fentanyl analogues with high selectivity and sensitivity. However, achieving high throughput with accurate quantification requires sophisticated sample preparation. Automated solid phase extraction (SPE) applied to fentanyl extraction with HP-SCX sorbent, offering reversed phase and strong cation exchange chemistry, addresses this challenge. Tecan highlights an automated workflow using the Resolvex® i300 and HP-SCX Narrow Bore Extraction columns (NBE columns™) to extract 23 fentanyl analogues from human urine efficiently.

In this video, Tecan introduces the Resolvex® i300, a positive pressure module for filtration, purification and solid phase extraction. An integrated component of the Fluent® automation workstation, the Resolvex i300 consolidates sample prep, cleanup, evaporation, and resuspension tasks into one operation. In addition to sample preparation for MS, Resolvex i300 can be configured to accommodate genomics based sample processing workflows. The video highlights the many features of the module including an integrated dispenser for up to 12 off-bed buffers and solvents.

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