Envisia
Envisia is a droplet-based single-cell platform that overcomes Poisson limitations to enable deterministic cell handling, sequential droplet merging, and iterative assays, unlocking true functional, phenotypic screening at the single-cell level.
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Envisia is a next-generation droplet-based, single-cell platform from Lightcast designed to move beyond the constraints of Poisson-driven workflows. Traditional droplet systems rely on random encapsulation, limiting control over cell pairing and assay complexity. Envisia uses optical electrowetting (oEWOD) technology and machine learning to precisely control droplet occupancy, positioning, and interactions, enabling deterministic single-cell workflows and eliminating reliance on probability-based loading.
This precise control allows for sequential droplet merging and iterative assay design, enabling researchers to interrogate cellular function across multiple steps. Cells can be paired, stimulated, assayed, and re-assayed in a controlled and programmable manner, supporting complex experimental designs that were previously not possible in droplet formats.
By integrating advanced instrumentation, a smart cartridge system, and intuitive software, Envisia delivers fully automated, contamination-free workflows with real-time monitoring. The ability to track, manipulate, and recover viable cells throughout multi-step processes enables true functional phenotypic screening, providing deeper insight into cellular behaviour and accelerating discovery in complex biological systems.
Key features & benefits
- Overcomes Poisson limitations with machine-learning for deterministic droplet control
- Enables sequential droplet merging for multi-step assays
- Supports iterative, programmable experimental workflows
- Precise control of droplet occupancy, position, and interactions
- Real-time hit selection and dispense with intelligent workflow automation
- Recovery of viable cells after multi-step functional screening
Applications - Functional phenotypic screening at the single-cell level
- Cell-cell interaction and pairing studies
- Immuno-oncology and cytotoxicity assays
- Sequential stimulation and response profiling
- Antibody discovery with functional validation
- Advanced assay development beyond Poisson-based systems
TechTalk: From technology scouting to real world single-cell functional analysis
Friday, May 22 at 15:00 BST | 16:00 CEST | 10:00 EDT | 07:00 PDT
Single-cell functional analysis is evolving rapidly, but identifying which technologies genuinely advance the science remains a challenge.
In this SelectScience® TechTalk, Toon Swings, Technology Expert at VIB Tech Watch, shares how his team scouts, evaluates, and stress-tests emerging single-cell platforms, and what criteria separate incremental from transformative advances.
Lightcast then presents Envisia, their oEWOD-based single-cell functional analysis platform, showing how programmable droplet control and machine learning address one of the field's most persistent bottlenecks: Poisson-limited encapsulation. Unlike platforms bound by fixed chip architectures, Envisia supports flexible, researcher-defined workflows across antibody discovery, cell line development, and cell and gene therapy applications.
Two perspectives. One question: what does genuinely useful single-cell functional analysis look like in practice?
Certificate of attendance
If you attend the live TechTalk, you will automatically receive a certificate of attendance, including a learning outcomes summary, for continuing education purposes.
If you view the on-demand TechTalk, you can request a certificate of attendance by emailing editor@selectscience.net.
TechTalk details
- Cost: Free to attend
- Location: Online
- Duration: 20 minutes
Registration is required to secure your place. If you register but can’t attend live, you will receive a link to the on‑demand recording once it becomes available.
