Octet® SF3 SPR System

This application note explores how OneStep® injections on the Octet® SF3 SPR system revolutionize small molecule and fragment-based drug discovery. By enabling real-time kinetic and affinity analysis from a single injection, OneStep® eliminates the need for serial dilutions and multi-cycle assays, saving time, sample, and cost. Learn how this method delivers high-content data with minimal setup, allowing researchers to screen hundreds of compounds rapidly and confidently.

This application note introduces NeXtStep™ injections on the Octet® SF3 SPR system, a powerful method for performing rapid, in-line mixing competition assays without the need for pre-mixed samples. Learn how this technique simplifies assay setup, reduces false positives, and enables accurate site-specific binding analysis. Featuring real-world examples with sulfonamides, the note demonstrates how NeXtStep™ enhances fragment screening and small molecule characterization with high sensitivity and efficiency.

In this video, discover the Octet® SF3 Surface Plasmon Resonance (SPR) instrument for high throughput hit identification. Designed with exceptional sensitivity for both small and large molecules, low baseline noise and drift, large injection volumes, and the novel OneStep® and NeXtStep™ Gradient Injection Technologies, hear how the new Octet® SF3 is designed to allow users to generate high-quality kinetics and affinity data in a fraction of the time compared to standard multi-cycle kinetics (MCK).

Sartorius Octet becomes the only brand to offer the two-leading label-free technologies: BLI and SPR