NHRCore Nuclear Receptor Directed Library

The NHRCore™ Library is a computationally selected library of more than 3,000 leadlike small molecules. NHRCore compounds are part of ChemBridge’s CORE Library stock and were selected for synthesis based on similarity to 3D pharmacophore fi ngerprints generated from published compounds with activity against nuclear hormone receptor targets.

ChemBridge® offers small-molecule sets targeted or focused towards specific targets or applications. The targeted and focused libraries originate from both their CORE Library stock and EXPRESS-Pick™ Collection stock of small molecule screening compounds. Clients can custom select/cherry-pick compounds from any of the sets.

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More than 1,500 articles cite the use of ChemBridge® small molecule screening libraries and compounds in a wide variety of research areas using high-throughput screening or focused screening following computer-aided screening. The list below highlights a small sampling of articles, from 2014 to present, that focus on work in cancer research and provides a sample of the different techniques employed and targets explored in hit finding and probe discovery using ChemBridge libraries and compounds.