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Incucyte® S3 Live-Cell Analysis System

Sartorius GroupView all modelsAvailable: Worldwide

Our flagship, supports the workflow and workload of larger laboratories.

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Average Rating 4.7

|6Scientists have reviewed this product

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Extremely great results. This is what we expect for and high quality for publication


Average Rating 5.0

Application Area:

Analyze Functional assay using plate reader in Incucyte.

We have been using the Incucyte machine for over 3 years now and I have to say that this machine by far is the best and easiest to use for functional assay as well as for screening of libraries. The quality of the output is great and I would surely recommend this to my collaborators and networking conference attendees.

Review Date: 23 Feb 2022 | Sartorius Group

Great potential, but ours was very sub-par for a $100+K machine. Poor reliability.


Average Rating 3.3

Application Area:

Analyze cell growth and/or differentiation morphology and markers

Our S3 had service-requiring issues almost immediately. Three total calls within the first 12 months, during a period in my new lab where it was only being occasionally used. Twice for the mechanics of the drawer, and once when they had to replace the motherboard. Then, right after our warranty expired, the machine needed the same exact repair as our second service trip, which would cost $7000. For a $100K machine, this level of service need is completely unacceptable. I cannot recommend this machine or this company to colleagues, which is a shame, because the promise of what the IncuCyte could do is very high.

Review Date: 10 Feb 2021 | Sartorius Group

Great results, we performed drugs testing and viability assay on this platform.


Average Rating 5.0

Application Area:

Cell biology

Incucyte S3 imaging system is a user free, reliable, ready to use, excellent instrument for cell biology research.

Review Date: 24 Dec 2020 | Sartorius Group

Can’t live without this equipment!


Average Rating 5.0

Application Area:


Our lab has been using Incucyte for many years. It is particularly useful for studying microglia cells. We mainly use Incucyte to track cell proliferation and cell death, as well as monitor microglial phagocytic activity. The software is easy to use, and the machine can accommodate multiple users at the same time. It is essential to our research.

Review Date: 2 Dec 2019 | Sartorius Group

Workhorse imaging!


Average Rating 5.0

Application Area:

Live imaging of drug response in neurons

The S3 is a perfect imager that produces high quality images even in phase contrast mode. We regularly are screening for neuro protective compounds in our iPSC model system where we can gain invalueable real-time data of response with images and graphs of 5 phenotypes of neurite changes. We can set up the images and times ahead of time with analysis in real-time and come back days later with super graphs of data. It is a highly-valued component of our research work.

Review Date: 2 Oct 2019 | Sartorius Group

Powerful and easy to use


Average Rating 4.7

Application Area:

Cell cycle, drug response

Intuitive controls and powerful software. Can get reproducible data easily. Companion kits make designing experiments easy.

Review Date: 25 Jul 2019 | Sartorius Group

The Incucyte® S3 Live-Cell Analysis System automatically acquires and analyzes images around the clock, enabling you to derive deeper and more physiologically relevant information about your cells, plus real-time kinetic data — without ever removing your cells from the incubator.

Change can happen in an instant. Whether simply assaying cell health or more complex processes like migration, invasion, or immune cell killing, see what your cells are doing and when they do it. The Incucyte® S3 instrument, proprietary assays and reagents provide you with the ability to gain new insights into biological processes via real-time, quantitative analysis of live cells.

Conventional approaches to cell analysis only capture a single time point, enabling only single-point and end-point measurements, and cells are perturbed or destroyed as part of the assay process. The Incucyte® system offers the advantage of performing live-cell analysis without ever having to displace cells or disrupt their surroundings. The system automatically and continually collects and analyzes images throughout the course of an experiment while cells remain unperturbed in a physiologically relevant environment. Furthermore, the Incucyte® S3 accommodates multiple users and applications seamlessly and combines information-rich, image-based analysis with the convenience and throughput of microplate assays.

Incucyte technology is featured in over 3,000 peer-reviewed publications in journals such as Nature, Chemical Society Reviews, Nature Medicine, and Nature Genetics, among many others. The S3 offers a completely reimagined user interface, enabling even first-time users to set-up an experiment and begin acquiring images within minutes. Image viewing, analysis and graphing is similarly streamlined – images from a 96-well experiment can be viewed simultaneously, then converted into movies, metrics, and corresponding publication- and presentation-ready graphs with just a few clicks. In addition to improving productivity for the individual user, the Incucyte® S3 empowers an entire research team. Multiple users can run multiple applications on the Incucyte® in parallel, reducing time spent waiting for an instrument to be available.

In addition, data is accessible remotely to any user via unlimited, free networked licenses. The Incucyte® and its unique features provide a powerful platform that enables researchers to devise new experiments not previously thought possible. In addition to the Incucyte® platform, Incucyte® proprietary reagents and analysis software are also available which enable researchers to perform real-time, quantitative live cell analysis and evaluate a wide variety of cellular processes over time.

Never miss powerful insights again, with the Incucyte® S3 live-cell analysis system, reagents, and consumables.

Key Features of the Incucyte® S3 Live-Cell Analysis System:

Ask new questions

  • Devise new experiments not previously possible
  • Conduct routine monitoring and get answers to unique scientific questions with kinetic, image-based measurements

Get new answers

  • Never miss a data point with real-time continuous analysis
  • Profile cell-specific and time-dependent biological activity
  • Visualize and validate results with images and movies

Improve productivity

  • Enjoy walk-away convenience as images are automatically acquired and analyzed
  • Multiplex measurements in 96- and 384-well assay formats
  • Accommodate multiple users and applications simultaneously

Protect your cells

  • Perform analysis without ever removing cells from the incubator or disturbing cultures
  • Maintain cell health and morphology with non-perturbing reagent formulations


  • Proliferation (confluence and cell counts)
  • Apoptosis (caspase 3/7 for live-cell imaging)
  • Cytotoxicity
  • Dilution cloning (whole-well imaging)
  • Migration / Invasion
  • Stem cell monitoring and reprogramming
  • 3D-Spheroids Angiogenesis
  • Neurite outgrowth and dynamics
  • Neuronal Activity
  • Reporter gene expression
  • Viral studies
  • Immune response – Immune cell killing
  • Antibody Internailization
  • NETosis
  • Phagocytosis
  • Immune cell clustering
  • Immunocytochmistry
  • Cell-by-Cell Analysis
  • Cell culture (& QC)

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