Human HepatoPac™ Kits
Human HepatoPac™ kits are an ideal way to conduct all your DMPK, Predictive Toxicology & Mechanistic Toxicology applications. Begin dosing as early as 3 days after receiving the kit! Use our Human HepatoPac™ Triple Donor plates for the ultimate in convenience. HepatoPac™ co-cultures derived from 3 independent and highly characterized donors are provided on a single plate (8-wells from each donor).HepatoPac™ kits can be used f…
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Acceptable quality.
Anticoagulant
Very expensive. Small quantities. Effective in limited time. Easy application.
Review Date: 21 May 2021 | Hepregen Corporation
Human HepatoPac™ kits are an ideal way to conduct all your DMPK, Predictive Toxicology & Mechanistic Toxicology applications.
Begin dosing as early as 3 days after receiving the kit! Use our Human HepatoPac™ Triple Donor plates for the ultimate in convenience. HepatoPac™ co-cultures derived from 3 independent and highly characterized donors are provided on a single plate (8-wells from each donor).
HepatoPac™ kits can be used for any assay that can be run using sandwich, monoculture plates or suspension cultures. Due to the extended in vitro functionality of HepatoPac™ co-cultures, Hepregen kits enable studies such as low turnover clearance or chronic toxicity studies that could not otherwise be performed.
Human HepatoPac™ Kits Features:
- HT-ready format; 24- and 96-well plates
- Proprietary micropatterened co-culture
- Superior data for both slowly and rapidly metabolized drugs
- Culture longevity of up to 4 weeks
Kits contain:
- Human HepatoPac™ Co-Cultures
- Maintenance Media
- Application-specific Media and additives
- Instructions for culture maintenance and application-specific protocols
- On-site customer training included
A Micropatterned Culture with Primary Hepatocytes and Kupffer Macrophages for Studying Inflammation-Drug Interactions
Using TVX as a prototype compound, this poster evaluates the ability of the HepatoPac- Kupffer cell co-culture model to detect inflammation- mediated toxicities.
Enhancement of Proliferation in a Novel Rat Hepatocyte Co-Culture Model after Mitogenic Stimulation
This poster examines several hepatocyte models to assess their usefulness to measure cell proliferation following mitogenic stimulation.
A Micropatterned Human Hepatocyte Co-Culture Model Allows Determination of Toxicity at More Relevant Concentrations than Hepatocyte Sandwich Cultures
This poster describes a study that was performed to determine if HepatoPac would allow for use of lower, more relevant concentrations of hepatocytes in toxicity studies than used with sandwich cultures.
Global Gene Expression Changes Induced in Primary Human Hepatocytes by Thiazolidinediones upon Repeat Dosing of HepatoPac Cultures
This poster demonstrates an attempt to discern the effects of acute (24 hours) and chronic (7 to 14 days) drug exposure on the transcriptome of primary human hepatocytes using the hepatotoxic and non-toxic drug pair, Troglitazone and Rosiglitazone, respectively.
Assessment of a Micropatterned Hepatocyte Co-Culture System to Detect Compounds that Cause Drug Induced Liver Injury in Humans
This poster demonstrates that for the detection of compounds that cause drug induced liver injury in humans, Human HepatoPac™ has a higher sensitivity than the conventional sandwich culture model.
Be Careful What You Ask for: Challenges of Predicting Human Clearance for a Low Metabolic Turnover Compound, ELND006
This application note aims to retrospectively evaluate allometry, microsomes, suspended hepatocytes and micropatterned co-cultures of hepatocytes and fibroblasts (HepatoPac) to estimate human CL of ELND006. And characterize the in vitro metabolic profiles of ELND006 generated with the HepatoPac system.
Micropatterned Primary Hepatocyte Co-Cultures for Drug Metabolism and Toxicity Studies
This application note describes a human liver model, HepatoPac, with precise microscale cyto-architecture and optimal stromal interactions (micropatterned co-cultures) that displays stable functions for several weeks in vitro.
<i>In Vitro</i> Modeling of Cytokine-Drug Interactions Using Micropatterned Co-Cultures Of Primary Hepatocytes and Kupffer Macrophages
Better predictive models for iDILI would enable the preclinical elimination of drug candidates with hepatotoxic liabilities. This poster describes a method in which HepatoPac co-cultures are supplemented with primary Kupffer macrophages for use in evaluating cytokine- drug interactions. Drug- induced stresses may interact with cytokine signaling to cause hepatotoxciity.
A Micropatterned Hepatocyte-Kupffer Cell Co-culture System to Study Inflammation in Drug Discovery
This application note highlights the supplementation of the HepatoPac platform with primary Kupffer cells in order to mimic an inflammatory environment such as cytokine production and altered CYP450 activity.
Bioactivation and Toxicity of Acetaminophen in Rat Primary Hepatocytes Cultured in Micropatterned Co-Cultures
This poster assesses the bioactivation and cytotoxicity of acetaminophen (APAP) as a function of culture age in a 96-well HepatoPac format.
SCIEX and Hepregen Announce Co-Marketing Agreement for Comprehensive Metabolite Identification Solution
Alliance establishes SCIEX and Hepregen as a one-stop solution provider for drug metabolism investigators
