Be Careful What You Ask for: Challenges of Predicting Human Clearance for a Low Metabolic Turnover Compound, ELND006

This application note aims to retrospectively evaluate allometry, microsomes, suspended hepatocytes and micropatterned co-cultures of hepatocytes and fibroblasts (HepatoPac) to estimate human CL of ELND006. And characterize the in vitro metabolic profiles of ELND006 generated with the HepatoPac system.