FlowSyn Continuous Flow Reactor
FlowSyn - Making Flow Chemistry Simple FlowSyn is a fully integrated continuous flow reactor with everything you need to start doing flow chemistry including reaction optimization, synthesis and scale up. To provide maximum flexibility, a wide range of mixer and reactor options are available as well as additional modules for performing multiple experiments, or sub-ambient chemistry. • Ability to perform continuous flow chemist…
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FlowSyn - Making Flow Chemistry Simple
FlowSyn is a fully integrated continuous flow reactor with everything you need to start doing flow chemistry including reaction optimization, synthesis and scale up.
To provide maximum flexibility, a wide range of mixer and reactor options are available as well as additional modules for performing multiple experiments, or sub-ambient chemistry.
• Ability to perform continuous flow chemistry under microwave-like conditions (up to 260oC).
• Perform sub-ambient continuous flow chemistry using the 'Cold Coil'.
• Run up to 10 automated sequential experiments with the 'Automated Experiment Package'.
A pair of high pressure pumps are used to deliver reagent solutions from either stock bottles or sample injection loops through a 'T'-mixer into the electrically heated flow reactors. Reactions can be heated to 260?C and 150?C in the coil and column reactor modules respectively. Back pressure regulators of up to 1000 psi are used to pressurise the system and thus perform superheating of solvents, allowing the chemist to access'microwave like' conditions with no limitation on scale.
FlowSyn is very easy to use with a high resolution user interface. The user is guided through the process for setting up a flow chemistry reaction by inputting parameters for reagent volumes, temperatures and reaction times. The user can choose to collect all of the reaction plug, or only the 'steady state' part. FlowSyn will then equilibrate and run the reaction, and finally flush the system through with solvent. Throughout FlowSyn will monitor the pressure of the system, and shut down if a problem occurs allowing FlowSyn to be safely run unattended.
Flow Synthesis: Reaction Optimisation and Scale-up in Meso-reactors
Continuous flow-through chemistry is an emerging technology for reaction optimisation and scale-up that has broad applicability in early stage drug discovery. In this application poster the FlowSyn™, an integrated bench-top continuous flow reactor, is used for an SNAr synthesis of a zyvox® intermediate, and a Knorr pyrazole synthesis reaction.
FlowSyn™: An Integrated Bench-top Continuous Flow Reactor
This application note demonstrates the capabilities of FlowSyn, a compact integrated continuous flow reactor. Two examples are presented: accelerated esterification under superheated conditions, and an aromatic nucleophilic substitution reaction.
A Safer Route to Organic Azides Using Segmented Flow
In this application poster a method is demonstrated of segmented flow for the synthesis of a range of organoazides. The outputs were used directly in subsequent reactions to afford the desired products in high yields and purities, minimising the handling of the toxic and hazardous intermediates.
Control of Mixing and Temperature using a Mesoscale Flow Reactor
Electrophilic bromination is a useful reaction in synthesis. However, when molecular bromine is used as the electrophile (under adventitious acidic conditions) it can be difficult to control both the exothermic addition and to prevent subsequent bis-bromination of the desired mono-brominated product. In this application poster, a series of flow-through conditions were investigated using the automated FlowSyn Multi-Experiment Package to quickly profile the bromination reaction.
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Sequential photothermal flow chemistry delivers high yields of bicyclic lactams
Researchers at the University of Bristol have successfully prepared bicyclic lactams in high yield and excellent purity, using a photochemical [2+2] cycloaddition followed by a thermal electrocyclic cascade
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