Uniqsis announces the FlowSyn Automated Loop Filling system

The exciting new automated product is designed to harness the power of flow chemistry to deliver more compounds faster

21 Jun 2020
Cameron Smith-Craig
Cameron Smith-Craig
Pharma and Applied Sciences Editor

The FlowSyn Auto-LF is a powerful and highly efficient module for running multiple experiments with multiple reagent inputs under different sets of chemical conditions.

This new product is ideal for robotic synthesis groups looking to generate combinatorial libraries utilizing the power of flow chemistry. Designed to run multiple experiments with multiple reagent inputs (with a choice of 2 or 4 channels) this intelligent simultaneous loop filling and fraction collection system saves valuable time by loading the reagent loops for the next reaction whilst the current run is in progress. Fully integrated wash protocols minimize the risk of cross-contamination.

FlowSyn Auto-LF incorporates an automated liquid handler that can accommodate up to 96 samples. Flow chemistry fractions can be collected either separately on a single rack fraction collector or on a 4-rack collector to further enhance your combinatorial chemistry throughput.

Utilizing Uniqsis's highly intuitive FlowControl software - the FlowSyn Auto-LF displays graphical real-time information (reactor(s) temperature, system, and individual pump pressures for reaction monitoring and data logging as well as flow rate/residence time. Setting up multiple reaction protocols is straightforward utilizing the FlowControl software’s wizard-based approach.

FlowSyn Auto-LF™ is compatible with Uniqsis HotCoil™, ColdCoil™, HotChip™ and PolarBear GSM™ reactors with an operating temperature range of -70°C to 300°C

Want more of the latest science news straight to your inbox? Become a member of SelectScience for free today>>

FlowSyn Continuous Flow Reactor

Uniqsis Ltd

FlowSyn - Making Flow Chemistry Simple FlowSyn is a fully integrated continuous flow reactor with everything you need to start doing flow chemistry including reaction optimization, synthesis and scale up. To provide maximum flexibility, a wide range of mixer and reactor options are available as well as additional modules for performing multiple experiments, or sub-ambient chemistry. • Ability to perform continuous flow chemistry under microwave-like conditions (up to 260oC). • Perform sub-ambient continuous flow chemistry using the 'Cold Coil'. • Run up to 10 automated sequential experiments with the 'Automated Experiment Package'.A pair of high pressure pumps are used to deliver reagent solutions from either stock bottles or sample injection loops through a 'T'-mixer into the electrically heated flow reactors. Reactions can be heated to 260?C and 150?C in the coil and column reactor modules respectively. Back pressure regulators of up to 1000 psi are used to pressurise the system and thus perform superheating of solvents, allowing the chemist to access'microwave like' conditions with no limitation on scale. FlowSyn is very easy to use with a high resolution user interface. The user is guided through the process for setting up a flow chemistry reaction by inputting parameters for reagent volumes, temperatures and reaction times. The user can choose to collect all of the reaction plug, or only the 'steady state' part. FlowSyn will then equilibrate and run the reaction, and finally flush the system through with solvent. Throughout FlowSyn will monitor the pressure of the system, and shut down if a problem occurs allowing FlowSyn to be safely run unattended.

(0)

Links

Tags

Uniqsis announces the FlowSyn Automated Loop Filling system