Cyto-Mine® Chroma
Unmatched Single-Cell Analysis with Multiplexing Power
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Cyto-Mine® Chroma is a multiplexing-capable, fully-automated single cell analysis platform that can encapsulate, analyze, sort, and dispense viable single cells.
Leveraging picodroplet technology, single cells are encapsulated in tiny volumes of liquid (e.g. cell culture media). Cyto-Mine® Chroma automates incubation of the cells and cellular output, proliferation, and/or interactions can be measured using standard fluor-based assays.
The automated system screens millions to tens of millions of viable single cells and simple controls allow users to select and dispense targeted desired cells for downstream outgrowth.
Features:
- Save time: Functionally analyze millions to tens of millions of single viable cells in a single day shortening standard workflows by months
- Enhanced detection: Able to detect secreted cellular products
- Easy to use: Simple-to-use workflows eliminate the need for extensive training on overly complex systems
- Flexible: Multiple assays provide flexibility in use cases and integration in your research pipeline
- Automated: Automate tasks that require manual labor and handoff between multiple pieces of equipment
High-throughput single cell analysis, sorting and dispensing using multi-laser picodroplet technology
Antibody therapeutics dominate drug development; however, lengthy workflows and rising costs in their discovery and development present significant challenges. Sphere Bio’s Cyto-Mine® system leverages picodroplet technology, microfluidics, and optics to overcome these hurdles in Antibody Discovery and Cell Line Development, accelerating therapeutic development. Here we introduce the next-generation Cyto-Mine® platform, Cyto-Mine® Chroma. This advanced microfluidic platform, equipped with multi-laser, single-cell analysis capabilities, enables high-throughput, multiplex functional screening of millions of cells in a single day.
Single cell analysis and isolation using multiplexing in picodroplets
The Cyto-Mine® Chroma is an advanced single-cell analysis and isolation platform that utilizes multiplexing in picodroplets to enhance antibody discovery and cell line development. Equipped with multiple lasers and detectors, it enables high-throughput screening with fluorescence-based multiplexed assays, ensuring accurate detection, sorting, and isolation of rare, antibody-secreting cells. Find out how its advanced gating and sorting capabilities allow for precise isolation of rare cells based on antibody-antigen binding, even in complex secretion assays.
Detection of Human Fc Fusion Proteins with Cyto-Mine
The Cyto-Cellect® Fc Fusion Detection Kit, optimized for use with the Cyto-Mine® Single Cell Analysis Platform, enables precise detection and selection of high-productivity Fc fusion protein-secreting cells through a FRET-based assay. This advanced tool streamlines single-cell screening and cell line development while maintaining an animal-origin-free workflow.
This application note highlights the kit’s effectiveness in detecting Fc fusion proteins with human IgG Fc domains. It demonstrates the kit’s compatibility with plate readers for reliable quantification of human Fc fusion proteins and IgG subclasses (IgG1-4). Additionally, in Cyto-Mine®, the kit successfully facilitated the isolation of Fc fusion protein-secreting cells, including those producing IgG4κ.
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