Cassette and Discrete PK Studies in Rat, Mouse, Dog, and Monkey for Small Molecules
Our Cassette and Discrete PK Study service evaluates pharmacokinetic profiles of small molecules in key preclinical species: rat, mouse, dog, and monkey. Using cassette dosing for high-throughput screening of multiple compounds simultaneously and discrete dosing for precise individual assessments for ADME parameters. This aids in early drug optimization, predicting human PK, and ensuring regulatory compliance for safer candida…
Cassette and Discrete PK Studies in Rat, Mouse, Dog, and Monkey for Small Molecules
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Our service offers both cassette dosing - administering multiple compounds together to accelerate screening and reduce animal use - and discrete dosing for accurate, compound-specific data without interference. Conducted in rodent (rat, mouse) and non-rodent (dog, monkey) models, it provides comprehensive PK parameters like clearance, volume of distribution, half-life, bioavailability, and mean residence time via serial blood sampling and LC-MS/MS analysis. Custom protocols simulate various administration routes (IV, PO, SC, etc) and include bioanalysis for plasma, tissues, and excreta, enabling cross-species extrapolation to predict human outcomes. This dual approach balances efficiency with precision, minimizing risks in lead selection.
Key features or benefits:
- Turnaround time: 1-2 weeks depending on study complexity
- High-throughput cassette: Screens multiple compounds per animal, saving time and resources
- Versatile species: Rodent and non-rodent models available
- Expert support: Full bioanalytical services, data interpretation, and regulatory-compliant reports
Relevant applications:
- Drug discovery: Rapid PK screening to identify promising small molecule leads
- Lead optimization: Refining compounds based on cross-species PK data
- Preclinical ADME: Assessing bioavailability and potential drug-drug interactions
