bioZen HPLC/UHPLC Columns
Explore Biozen LC Portfolio
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Great solution for analysts in this particular field of applications.
Analytics of proteins
Priority over others is faster system set-up, which is very important in the analysis of proteins. The column is also less affected by these protein samples, since there is no need for repeated sample injections for system equilibration.
Review Date: 15 Mar 2019 | Phenomenex Inc
Nice product.
Reversed phase chromatography
It's a good product. It enables high quality results. It was easy to use.
Review Date: 18 Feb 2019 | Phenomenex Inc
With a new titanium BioTi™ biocompatible hardware to minimize priming, four particle platforms for optimal versatility and nine particle chemistries to maximize selectivity and sensitivity, Biozen UHPLC/HPLC columns are seamlessly designed to bring peace of mind to your analysis of biologics.
Brochures
New Biozen size exclusion chromatography columns
This product brochure provides an overview of the bioZen size exclusion chromatography columns, which feature advanced SEC silica particle technology, improved column lifetime, and performance stability.
Achieve better resolution for large biologics
This product brochure by Phenomenex demonstrates a new solution for your intact mAbs and subunit analysis using bioZen™.
Biosimilars chromatographic characterization guide
In this brochure, discover how bioZen columns aid in analyzing infliximab and biosimilars through primary structure, higher order structure and post-translational modifications.
bioZen Product GuideAll You Need to Know About bioZen HPLC/UHPLC Columns
This product brochure provides an overview of the bioZen HPLC/UHPLC columns, which feature a new titanium biocompatible hardware to minimize priming, two particle platforms for optimal versatility and seven particle chemistries to maximize selectivity and sensitivity.
Biologics Workflow: Aggregate Analysis by Size Exclusion Chromatography
This product brochure provides an overview of aggregate analysis using the bioZen SEC columns, which were developed with a combination of UHPLC efficiency and higher sensitivity, to drive resolution and identification of even lower level targets.
Peptide mapping of adeno-associated virus capsid proteins
In this application note, Phenomenex profiles capsid protein peptides from AAV5 and AAV9, digested with trypsin using a BioZen™ Peptide XB-C18 reversed phase column. The use of adeno-associated viruses (AAV) as an effective vector for the delivery of ssDNA in gene therapy, is well established and continues to grow. As with any protein, viral proteins (VPs) are subject to post-translational modifications that can impact stability, capsid assembly, and overall efficacy. As a result, peptide mapping can be used to evaluate the presence and identification of these modifications.
Intact identification of adeno-associated virus capsid proteins
In this application note, Phenomenex profiles denatured and dissociated capsid proteins from AAV5 and AAV9, via analysis with LC-MS using a BioZen™ Intact XB-C8 reversed phase column. The use of adeno-associated viruses (AAV) as an effective vector for the delivery of ssDNA in gene therapy continues to gain momentum. A chief attribute to this success is the broad tissue tropism enabled by a range of serotypes. To date, approximately 13 different serotypes have been identified with a range of shared amino acid sequence identity. Structurally, the viral capsid is a sixty-protein icosahedron comprised of three capsid, or viral proteins (VP), non-covalently assembled in a ratio of 1:1:10 (VP1:VP2:VP3).
Size Exclusion Chromatography FAQs from Biozen
In this application note, Phenomenex provides answers to frequently asked questions on Size Exclusion Chromatography. Download to gain expert technical advice on installation, storage, methods, and more.
Biozen dSEC-2 guard columns
In this application note, Phenomenex challenges the bed stability of the dSEC-2 guard column by testing efficiency over a prolonged period of time continuously running mobile phase.
Method development for ADC Kadcyla by Size Exclusion LC using a Biozen™ dSEC-2 Column
In this application note, Phenomenex explores method development using standard phosphate containing buffers with different percentages of Isopropanol for aggregate analysis of an antibody-drug conjugate (ADC), Kadcyla.
Oligonucleotide analysis by Size Exclusion using a Biozen™ dSEC-2 Column
In this application note, Phenomenex demonstrates the utility of Size Exclusion Chromatography for the detection of high-order structure of single-stranded DNA oligonucleotides by size exclusion.
Size Exclusion analysis following IdeS digestion using a Biozen™ dSEC-2 Column
In this application note, Phenomenex demonstrates the analysis of antibodies using enzymatic digestion. Specifically, Phenomenex uses the cysteine protease IdeS, which cleaves IgGs below the hinge region and yields a Fab’2 & two Fc/2 fragments.
Effect of different column lengths in SEC using Biozen ™dSEC 2 columns
Column length can be a powerful tool with which to improve chromatographic resolution, particularly when working with size exclusion chromatography (SEC). In this application note, Phenomenex discusses the impact of column length when performing SEC using Biozen dSEC-2 LC columns.
Effect on resolution in SEC comparing different particle sizes and column sizes of Biozen™dSEC-2 columns
In this application note, Phenomenex presents a method for investigating the effect on resolution in SEC when using different particle sizes and column sizes of Biozen dSEC-2 columns.
Resiliency of larger particle sizes to systems of differing dwell volume in SEC using Biozen™dSEC-2 column
When looking to develop a transferrable robust method, careful consideration to the column dimensions should be given, including particle size. In this application note, Phenomenex presents a method to illustrate the ability of larger particle sizes to accommodate different dwell volumes.
Workflow considerations for advanced PFAS/GenX LC-MS/MS sample preparation and chromatography
Watch the new on-demand webinar to learn more about underlying chemistry considerations for PFAS and GenX compound analysis
Webinar Highlights: Discover a Simple way to Characterize Biosimilars and Proteins
Supporting biosimilar and protein characterization complexity with novel bio-inert hardware
