ACQUITY Arc System
HPLC and UHPLC method compatibility at the flip of a switch.
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Great results, necessary to adapt these instruments!
Implementation of Analytical Method Development by using QbD principles
To implement QbD concepts in analytical method development, necessary to generate the DoE in the screening experiments. Also, numerous experiments have to conduct to produce the MODR. Acquity Arc HPLC plays a pivotal role in fabricating chromatographic data without losing precision and accuracy. In addition, it is easy to operate with the Empower software. Service from the waters is easily accessible after installation in our laboratory. They will resolve the issues quickly. Overall it is a value-for-money product and helps to improve laboratory efficiency.
Review Date: 27 Sept 2022 | Waters
Great instrument
Analysis
Great ruggedness, good instrument
Review Date: 26 Apr 2022 | Waters
Good analysis in short time
Analize organic synthesis products
The software has medium ease of use. Waters takes care of the customer after sales
Review Date: 21 Apr 2022 | Waters
Powerful hardware components and easy to operate software for method validations.
Pharmaceuticals
Reproducible results with related substances analysis in APIs / Nitrosamines estmation at 5 ppb level was achieved using QDa detector
Review Date: 11 Feb 2022 | Waters
Versatile system
Assay and Related Substances on small molecules
The system has 2 flow paths and allows you to perform "normal" HPLC as well as entering the space of UHPLC. With the increase in pressure limits, using columns with smaller particle size is much easier. Although the system is not a "true" UHPLC, it allows one to see the impact of system dwell volume and as a result understand the impact on your separation.
Review Date: 8 Feb 2022 | Waters
I advise scientists to buy this system
Qualitative and quantitative and of raw materials
Very easy to use, secured and accurate results
Review Date: 7 Feb 2022 | Waters
Great results, can't live without this instrument!
Medicinal premixes, soluble powders and other animal health products.
Our lab currently has three ACQUITY Arc systems, with plans to add more in the immediate future to increase capacity. The systems run constantly and are critical to the business. These systems are highly effective in meeting the analysis needs of our lab, and I really don't think we could function without them. Compared to competitor HPLC systems that these replaced, the quality and integrity of the data is much higher, reproducibility was also improved. Analysts find the ACQUITY Arc system easier to use and less time is required to train users to a level of independence using the systems. For these reasons, ease of use received a 5-star rating. Post-sale service and support from the local Waters' service team is legendary! Service is prompt, thorough, courteous and compliant. Working in a regulated environment, the support after the sale is paramount and Waters' delivers exceptional support! For these reasons, both value for money, and after-sales care receive a 5-star rating. Looking at the complete package - instrument, software, support, qualification - Waters' offerings are, in my honest opinion, a fantastic value and worth every penny!
Review Date: 21 Jan 2022 | Waters
Great and accurate results.
Quantitative and qualitative analysis of raw materials and pharmaceutical products
It is very easy to use and gives more control.
Review Date: 23 Jul 2021 | Waters
Very easy and accurate results.
Quantitative and qualitative analysis
Very sensitive and good instrument.
Review Date: 16 Jul 2021 | Waters
Great and accurate results
Quantitative and qualitative analysis
Very accurate and fast
Review Date: 2 Feb 2021 | Waters
The ACQUITY Arc System is a quaternary-based, modern LC system for scientists working with established methods who are looking for the versatility and robustness required to bridge the gap between HPLC and UPLC while continuing to support validated assays.
The ACQUITY Arc System can replicate your established HPLC methods by compensating for these differences with unique features such as the Arc Multi-Flow Path technology and Gradient SmartStart. These innovative attributes enable seamless replication of your existing chromatographic results to meet your acceptance criteria without changes to validated gradient tables.
Get seamless and efficient transfer, adjustment, or improvement of methods from any LC platform without compromise in method integrity or changes to validated gradient tables.
The ACQUITY Arc System is enabled by Arc Multi-flow path technology, novel technology that enables the user to easily switch between HPLC and UHPLC operation by selecting the dwell volume that best fits the column separation. System reliability and robustness ensures product consistency and compliance with regulatory guidelines, all while minimizing downtown and inefficiencies.
With the ACQUITY Arc System, maximize productivity through combining system dispersion characteristics with efficient and rapid 2.x um UHPLC separations. Or, accommodate larger, 3.0 - 5.0 um particles. This provides the flexibility to support a wide-range of LC applications.
Get an LC-MS solution that's as easy to use as photodiode array detection. The ACQUITY Arc System is fully compatible with the ACQUITY QDa Detector, supporting routine analysis applications and expanding the information you can get from your system using the same Empower Software.
Features:
- Quaternary solvent blending. Blend up to four solvents in any combination or proportion. Expand to up to nine solvent choices with the optional and integrated solvent-select valve for even greater flexibility.
- Plug-and-play method compatibility with HPLC or UHPLC with the flip of a switch. Easily replicate or improve established methods by simply selecting Path 1 (HPLC) or Path 2 (UHPLC) without any manual user intervention. Automatically counteract differences in system dwell volume without the need to alter gradient table inputs.
- Minimize carryover (<0.002%) by continuously cleansing the needle during the run with an advanced flow-through-needle design.
- Flexible column management, providing stable, uniform temperature management with integrated pre-heating options to ensure method repeatability from lab to lab. Optional and integrated column selection valve provide fast, unattended column changeover.
- Directly program gradients in units of pH and ionic strength with Auto●Blend Plus Technology, providing the ability to vary composition in even the smallest increments of pH. This eliminates the cumbersome and error-prone approach of manually preparing mobile phase solutions.
- Ensure method repeatability from lab to lab with column heater and column heater/cooler options.
- Maximize HPLC and UHPLC performance with a full line of optical detection options.
- Push-button mass detection with the ACQUITY QDa Detector.
- Compliance-ready. Qualification of laboratory instrumentation is an integral part of compliance with regulatory and quality standards such as GMP, GLP, ISO 17025, USP <1058>, and others. The ACQUITY Arc System supports Waters Empower based automated system qualification tool (SQT), which minimizes the time and cost associated with annual qualification.
- Supported in both Empower and MassLynx Software.
Brochures
Waters chromatography solutions
In this brochure, Waters™ chromatography solutions are presented as critical components for achieving reliable, consistent, and defensible data in a variety of lab scenarios, addressing key issues such as spec compliance, safety validation, understanding diseases, and identifying effective treatments. Waters provides a comprehensive portfolio that helps laboratories produce quality data and prepares them for future opportunities, ensuring that results are accurate and compliant with the latest guidelines. Waters Chromatography Solutions are highlighted as a comprehensive and adaptable suite of tools and systems that support critical laboratory analyses while ensuring compliance, scalability, and reliability.
Waters automation portal solution
In this application note, Waters™ describes how the Automation Portal enhances laboratory efficiency, throughput and consistency by automating the ACQUITY™ and Arc™ UPLC™, UHPLC, and HPLC Systems. It accomplishes this by streamlining the liquid chromatography (LC) workflow, specifically through the use of robotic arms to manage physical sample transfers into ACQUITY and Arc Sample Managers, thus reducing the potential for analyst errors. Waters emphasizes the Portal's versatility, as it can work with scheduling software for managing laboratory tasks and can integrate with different lab environments and preferred integration partners.
Determination of low level lactose in dairy products using UHPLC-MS
Download this application note to find a method that demonstrates how UHPLC-MS is suitable for lactose determination in dairy products, including low lactose and lactose-free dairy products.
Quantification of mono and disaccharides in foods
Monosaccharides fructose, galactose, and glucose, and disaccharides sucrose, lactose, and maltose are common sugar ingredients in foods. This application note demonstrates the accurate and reliable determination of sugar content in food and animal feed samples.
Fast Analysis of Isoflavones in Dietary Supplements – Method Transfer to an ACQUITY UPLC H-Class System
In this application note, the efficacy of different methods for the determination of isoflavones in dietary supplements was determined. The standard methods are based on reversed-phase high-performance liquid chromatography (RP-HPLC) and ultraviolet and visible light (UV-VIs) spectroscopy detection. By transferring a new isoflavones standard method onto the ACQUITY Arc UHPLC System, the run time of the analysis was cut from 70 minutes to 18 minutes.
Developing Analytical Chromatographic Methods for Pharmaceutical Stability Investigations
This application note describes a case study where Quality by Design approach was used to develop an analytical stability indicating method for monitoring degradation of amoxicillin powder for oral use.
Demonstration of USP Quetiapine Fumarate Impurities Method Across a Wide Range of LC Systems
In this application the USP quetiapine fumarate impurity method is analyzed on three different LC systems including the Alliance HPLC System, the ACQUITY Arc UHPLC System, and the ACQUITY UPLC H-Class PLUS System. The successful execution of the method on each system will be evaluated based upon the system suitability requirements listed in the USP monograph.
Transfer of USP Assay for Quetiapine Fumarate Across Different LC Systems
In this study, the USP assay method for quetiapine fumarate, an anti-psychotic drug, will be evaluated on a range of systems including an Alliance HPLC System, an ACQUITY Arc UHPLC System and an ACQUITY UPLC H-Class PLUS System. The USP method for quetiapine fumarate was successfully transferred across three systems: an Alliance HPLC System, an ACQUITY Arc UHPLC System, and also an ACQUITY UPLC H-Class PLUS System. All three instruments were able to reproduce the percent of quetiapine fumarate in an unknown sample and meet system suitability requirements, including resolution, tailing factor, and repeatability specifications required by the USP quetiapine fumarate assay method.
Scaling of a USP Assay for Quetiapine Fumarate Across Different LC Systems
In this study, the Waters Columns Calculator will be used to scale the USP monograph assay method for quetiapine fumarate an anti-psychotic drug, to smaller particle sized columns.
Utilizing the method scaling guidelines within the USP General Chapter <621>, traditional isocratic HPLC methods are capable of being scaled to columns with smaller particle sizes and shorter lengths. Scaling a USP method enables the use of modern chemistries and LC hardware to deliver improved throughput with decreased solvent consumption all while providing accurate and reproducible chromatographic data. The scaled modifications for the USP quetiapine fumarate assay method enabled the original method run time to be reduced by 57% for a 3 μm column on an ACQUITY Arc UHPLC System and 87% reduction for the 1.7 μm column on an ACQUITY UPLC H-Class PLUS System. The scaled methods maintained the same or improved chromatographic performance in terms of resolution, peak tailing, and retention time and peak area RSD.
Determination of Isoflavones in Dietary Supplements: A Comparison of Mass Detection with UV Detection
This study demonstrates that in the analysis of complex samples, such as plant extracts, the use of mass detection greatly reduces the interferences from co-eluting compounds. Also, time-consuming troubleshooting for out of specification results are reduced, which will in turn improve overall lab productivity and analytical data quality.
Waters Application Notes: Food Testing : Introducing the Xevo TQ-XS
In this collection from Waters, you will find a range of application notes covering the areas of food quality control, research, and safety. Find out how to rapidly screen fatty acids in oil supplements, test for pesticide residues in dried botanicals, and much more.
Eliminating doubt in liquid chromatography
In this video, discover how Waters Corporation aims to help provide you with the confidence that your method is consistent and reproducible, batch-to-batch, year-to-year with attention to detail to column particle and manufacturing processes to supply chain and customer support.
How a focus on quality is driving efficiency in the QC lab
In this video debate, Fernando Bustos, senior quality manager at Perrigo, and Adriana Tirado, market development specialist at Waters, discuss topics on the importance of QC, meeting regulations, chromatography solutions and how Waters can help you overcome challenges associated with QC.
The Impact of Mass Spectrometry on Biomedical Research
Understand the value of accurate and precise measurement in biomedical research: Professor of Medicine, Dr. Stokes Peebles, and Research Associate Professor of Medicine, Dr. Ginger Milne, from Vanderbilt University School of Medicine, discuss how mass spectrometry provides analytical rigor not achievable with immunoaffinity technologies.
Waters ACQUITY Arc Wins Best New Separations Product of 2015
Eric S. Grumbach, Product Manager of the Waters AQUITY Arc LC system, shares his thoughts on winning the Scientists’ Choice Award® for Best New Separations Product of 2015.
ACQUITY Arc System for HPLC and UHPLC
This video from Waters Corporation introduces the Acquity Arc System, a true plug-and-play method compatibility for HPLC and UHPLC separations.
Auto Blend Plus for Managing LC Mobile Phase Composition
In this video Waters Corporation demonstrate using AutoBlend Plus, which allows you to program your LC to create mobile phase compositions at a specific pH and ionic strength, making it easier than ever to get the best analytical method for your sample.
Bridging the Gap Between HPLC and UPLC: The Ground-Breaking ACQUITY Arc System from Waters
In this video, Dr Eric Grumbach, Workflow Integration in Separations Technology at Waters Corporation, explains how the ACQUITY Arc System is ideal for QA/QC and routine testing laboratories. The ACQUITY Arc allows scientists to alternate between the established separating power of HPLC and the speed and productivity of UHPLC at the flick of a switch. The Arc Multi-Flowpath technology allows fast method optimization for bringing existing HPLC methods to UHPLC.
Discover the LC System Portfolio from Waters
In this video learn about the Waters portfolio of LC Systems that provide reliability, robustness and reproducibility to meet your application goals. The alliance HPLC provides consistent results, the Acquity Arc offers the flexibility to run both HPLC and UHPLC methods, and the Acquity UPLC H Class system improves lab efficiency.
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Modern LC System replicates established test methods, delivers improved performance; updates to lab business continuity solution also announced
10 top-rated lab products win Seals of Quality at Virtual Summit on Cancer and Immunology Research
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An Introduction to Analytical Procedure (Method) Lifecycle Management: Register for Our Upcoming Webinar with Experts from the US Pharmacopeia and Pharmaceutical Industry
Learn about the benefits of the Method Lifecycle Management approach and how to implement this approach in your lab
How Will Pharmacopeial Modernization Benefit Your Chromatography Workflow? Your Questions Answered
Dr. Leonel Santos and Dr. Horacio Pappa of the United States Pharmacopeia (USP) describe pharmacopeial modernization efforts in this on-demand webinar
What's The Right Liquid Chromatography System for You?
In this article, we compare quaternary LC systems to help you choose the best for your analysis needs
Waters’ Centers of Innovation Program Recognizes Forensic Chemistry Laboratory at the University of Copenhagen
Laboratory applies analytical chemistry to solve drug-related crimes
Webinar Highlights: Life Cycle Management of Chromatographic Methods for Biopharmaceuticals
Read the highlights from our recent webinar on chromatography for biopharma
Revolutionary Open-Access Laboratory Facilitating Innovative Research
Learn how innovations from Waters keep this lab at the cutting edge
Video Highlights from HPLC 2015
Select Science reports on the latest technologies from HPLC 2015
