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The 11BHSD2 mouse was produced by injection of a construct, containing 11β-HSD2 cDNA isolated from mouse kidney and cloned into plasmid Clone 26 to recruit the 5.4 kb mouse α–myosin heavy chain (α-MHC) promoter, into pronuclei of C57BL/6 e... Read more...
NSE-p25 mice were created by pronuclear injection of an NSE-p25 transgene, produced internally at Pfizer, with transplantation of embryos to pseudopregnant CD-1 females.
At weaning genomic DNA was isolated from tail tissue and founder... Read more...
The PhysioTel F20-EET and F40-EET transmitters are designed primarily for sleep research applications in rodents. These transmitters will allow simultaneous monitoring of two biopotential channels, such as EEG and EMG, temperature, and lo... Read more...
In vivo model for cardiovascular, alzheimer’s and other neurodegeneration studies.
Apolipoprotein E (ApoE) is a critical apoprotein of the chylomicron which binds to a specific receptor on liver cells and peripheral cells. Defects in ... Read more...
Rabbits are a preferred model in hypertension and atherosclerosis studies due to their convenience of various physiological and surgical manipulations. ApoE Knockout rabbits have drastically elevated cholesterol and triglycerides, making i... Read more...
Developed in collaboration with The Michael J. Fox Foundation, this model contains a deletion of the Pink1 (PTEN-induced putative kinase 1) gene, encoding for a serine/threonine protein kinase.
Mutations in Pink1 are implicated in ear... Read more...
This model contains a biallelic deletion within the Disc1 (disrupted in schizophrenia 1) gene, encoding the DISC1 protein.
A translocation disrupting Disc1 was discovered to co-segregate with major psychiatric illness in a Scottish fa... Read more...
This model contains a biallelic deletion of the neuroligin 3 gene (Nlgn3). Mutations in Nlgn3 have been linked with autism and Asperger’s syndrome.
This model is useful for understanding the role of neuroligins in the development of a... Read more...
This model expresses cre-recombinase under the control of the endogenous tyrosine hydroxylase promoter enabling specific expression in dopaminergic neurons.
This model possesses a targeted insertion of (IRES)-cre immediately after the... Read more...