Effectiveness of the AC extraction plate for protein removal
6 Nov 2024When determining small molecules in biological matrices by liquid chromatography mass spectrometry (LC/MS), it is important to ensure that the sample preparation steps remove any interfering matrix components prior to sample injection. Common procedures to remove proteins can be complex and time consuming. Explore how simple procedures can be applied with the Tecan AC Extraction Plate to remove proteins from a sample matrix, and that the protein is not retained in the TICE™ coating covering the lower part of the plate’s wells.
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AC Extraction Plate™
TecanThe Tecan AC Extraction Plate* with TICE™ (Tecan Immobilized Coating Extraction) technology revolutionizes your sample preparation routine. The AC Extraction Plate is a 96-well, deep-well microplate, with each well having a proprietary TICE™ coating. TICE is a material with distinct absorptive properties, and this coating efficiently extracts specific small molecule analytes from aqueous solutions, releasing them when in contact with a suitable organic solvent. A simple pipette and shake sequence, with no filtration, centrifugation or solvent evaporation, is all that is required. The AC Extraction Plate is easily integrated into automated processes, making it a perfect match with Tecan’s Freedom EVO® liquid handling platform. AC Extraction Plate™ Features: Cost-effective – Simple pipette and shake workflow, without labor intensive centrifugation, filtration and solvent evaporation steps. Convenient and fast – Just unpack and start, no conditioning or other preparations needed. Highly reproducible – Pipette and shake routines are easily standardized and automated on a liquid handling platform, eliminating random errors and increasing consistency of results. * For research use only – not for clinical diagnostic applications