ResourceSeparations

Solutions for Mass Spectrometric Detection

29 Jan 2015

This compendium of selected articles is intended to help and support users of chromatographic separation methods in mass spectrometric laboratories worldwide, by providing an overview of different actual topics in this field of analytical science.

Chromolith® High Resolution HPLC Columns

Merck KGaA, Darmstadt, Germany

Chromolith® HighResolution: High resolution separations without ultra high pressure. The revolutionary monolithic Chromolith® HighResolution columns are made from a single rod of high-purity monolithic silica, rather than from particles. Their unique bimodal pore structure allows the chromatographic performance to be improved significantly. Speed of analysis (separations up to 9 times faster if required) Separations two times faster at half the column back-pressure compared to μm columns Higher sample throughput Improved HPLC system security Significantly increased column lifetime Reduced maintenance on HPLC pump and injector seals Reduced need for sample preparation as columns are very resistant to blocking (even with biological samples) Column length no longer pressure limited Very high separation efficiency by column coupling

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Solutions for Mass Spectrometric Detection