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Rapid thermal stability screening of high concentration biologic drugs

TA Instruments - Waters LLC
22 May 2026

Biotherapeutic thermal stability testing is crucial to ensure product quality and support regulatory approval of biologic drug products. The TA Instruments RS-DSC (Rapid Screening-Differential Scanning Calorimeter) provides a platform for simultaneous analysis of up to 24 samples. Further, high concentrations of protein drug candidates can be evaluated using low-volume disposable microfluidic chips. This application note provides data illustrating the utility of the TA Instruments RS-DSC by evaluating the limit of detection and demonstrating the range of concentrations amenable to differential scanning calorimetry (DSC) analysis.

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Rapid Screening-Differential Scanning Calorimeter

TA Instruments - Waters LLC

The Next Generation of Thermal Stability Testing for Biologic Drugs The TA Instruments RS-DSC (Rapid Screening-Differential Scanning Calorimeter) is a powerful and versatile instrument that revolutionizes the thermal stability testing of biologic drugs with its high efficiency and streamlined analysis.

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CalorimetryCalorimetry is a technique used to determine the heat released or absorbed in a chemical reaction. Calorimeters can be categorized into bomb calorimeters, constant pressure calorimeters, differential scanning calorimeters, isothermal titration calorimeters, X-ray microcalorimeters, heat-loss calorimeters, and high-energy particle calorimeters. The choice of calorimeter depends on the application.Thermal Analysis EquipmentThermal analysis equipment is used for measuring heat flow, weight loss, dimension changes or thermomechanical properties and is important for analyzing a material’s performance and stability. Thermal analysis equipment includes differential scanning calorimeters (DSC), thermogravimetric analyzers (TGA), thermomechanical analyzers (TMA), dilatometers, thermometers, vapor sorption analyzers, boiling and melting point apparatus. Thermal analyzers can reveal properties such as melting, crystallization and glass transitions or other processes such as oxidation, decomposition, volatilization, as well as coefficients of thermal expansion and modulus. Find the best thermal analysis equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.BiologicsBiologics are medical products derived from living organisms, including vaccines, gene therapies, and monoclonal antibodies. These treatments are key to modern healthcare, especially in oncology and autoimmune diseases. Explore biologics research tools in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.Drug DevelopmentDrug development refers to the process of bringing a new drug to market.FormulationFormulation is the process of combining active pharmaceutical ingredients with excipients to produce a drug which is both stable and active.

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