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Rapid high-throughput amino acid analysis of GLP-1 analogs

16 Oct 2025

Due to increased demand for glucagon-like-peptide-1 (GLP-1) receptor agonist based drugs, manufacturers are continually looking for fast and reliable solutions to screen and evaluate products to ensure that they meet regulatory standards. Amino acid analysis is a quantitative approach to assess composition and optimize bioprocess parameters during drug production, but often require lengthy hydrolysis and derivatization steps.

In this study, a microwave-assisted UPLC™ workflow is demonstrated, designed to rapidly hydrolyze, label, and identify amino acids in GLP-1 analogs using Waters AccQ·Tag™ Ultra Chemistry Kit as a turnkey solution to expedite amino acid analysis of GLP-1 analogs.

ACQUITY Premier System

Waters

Along with the reliability, ruggedness, high quality, and configuration flexibility you expect from the ACQUITY™ UPLC™ PLUS Series, the Waters™ ACQUITY Premier System delivers a step change in chromatographic performance, lab efficiency, and risk control.

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Empower™ Chromatography Data System

Waters

The Empower Chromatography Data System is Waters’ compliance-ready chromatography data software (CDS) for advanced data acquisition, processing, and reporting that simplifies the management of chromatography test results.

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biopharmaceutical analysisAmino AcidsHigh Throughput AnalysisLiquid ChromatographySample ProcessingSample processing is required to prepare samples prior to analysis. Technologies used for sample processing include homogenizers, grinders, mills and mixers.
Rapid high-throughput amino acid analysis of GLP-1 analogs - SelectScience resources