Rapid Analysis of Benzodiazepines in Urine and Whole Blood Using LC/MS/MS and an Ultra Biphenyl Column
11 Feb 2015In this application note, a rapid, sensitive method for the routine analysis of benzodiazepines in urine and whole blood was developed using a simple dilute-and-shoot methodology. This method, which uses an Ultra Biphenyl LC column and an API 4000 MS/MS detector, provides a fast 4.5 minute analysis which allows efficient monitoring of a broad range of benzodiazepines at therapeutic levels.
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Ultra Biphenyl Columns
Restek Corp.Properties: Increased retention for dipolar, unsaturated, or conjugated solutes. Enhanced selectivity when used with methanolic mobile phase. Ideal for increasing sensitivity and selectivity in LC-MS analyses particle size: 3 μm or 5 μm, spherical pore size: 100 Å carbon load: 15% endcap: fully endcapped pH range: 2.5 to 8 temperature limit: 80 °C USP phase: L11 phase category: phenyl ligand type: unique Biphenyl