Next-level performance in label-free high-throughput screening of protein-ligand interactions with timsTOF MALDI PharmaPulse

9 Aug 2024

The timsTOF MALDI PharmaPulse® (timsTOF MPP) represents an advanced label-free high-throughput screening (HTS) solution for small-molecule ligand binding assays. Leveraging MALDI mass spectrometry's speed and robustness, combined with Bruker's timsTOF technology, timsTOF MPP enables rapid, accurate, and high-resolution detection of protein-ligand interactions. Explore the results of a study describing the first-time application of timsTOF MALDI PharmaPulse® (timsTOF MPP) for high-throughput screening (HTS) of protein-ligand interactions using label-free affinity-selection mass spectrometry (AS-MS).

timsTOF MALDI PharmaPulse

Bruker Daltonics

Gain new insights into molecular interactions and accelerate drug discovery with timsTOF MALDI PharmaPulse ® - the innovative technology for high-resolution label-free HTS.

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Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Label-Free Analysis
Next-level performance in label-free high-throughput screening of protein-ligand interactions with timsTOF MALDI PharmaPulse