timsTOF MALDI PharmaPulse
Gain new insights into molecular interactions and accelerate drug discovery with timsTOF MALDI PharmaPulse ® - the innovative technology for high-resolution label-free HTS.
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- Speed & Robustness: Experience true ultra-high-throughput screening with fast reading rates of up to 3 wells per second and proven MALDI robustness with timsTOF MALDI PharmaPulse.
- TIMS Enabled: Gain a new level of separation and awareness with Trapped Ion Mobility Spectrometry (TIMS) - a first-ever feature in HTS - for ultrafast separation and superior results.
- Specificity: Achieve superior results with high-resolution, accurate-mass QTOF-MS combined with TIMS separation of isobars and isomers, providing unmatched performance in various high-throughput applications, including unbiased, deep HTS by label-free mass spectrometry.
Brochures
Unbiased high-throughput screening by label-free mass spectrometry
Discover Bruker's timsTOF MALDI PharmaPulse®, a unique platform for near real-time verification of chemical synthesis products. Keeping the pace of synthetic chemistry high-throughput experimentation (HTE) in early drug discovery, and providing access to an expanded analyte space by means of MALDI-2 laser post-ionization technology.
Analytik Jena MALDI sample preparation configuration overview
Discover the Analytik Jena MALDI Sample Preparation configurations. The Analytik Jena MALDI Sample Preparation is the tailored and automated uHTS MALDI sample preparation for powerful and unique label-free detection capabilities of Mass Spectrometry.
Integrated uHTS MALDI Sample Preparation and Mass Spectrometry with Analytik Jena and Bruker’s timsTOF MALDI PharmaPulse
Discover the collaboration between Analytik Jena and Bruker, bringing you a cutting-edge liquid handling automation solution tailored for drug discovery screening. This innovative system integrates Bruker's MS System timsTOF MALDI PharmaPulse® with Analytik Jena's automated ultra-high throughput screening (uHTS) MALDI sample preparation. It provides a seamless combination of label-free mass spectrometry detection and high-efficiency sample processing.
Next-level performance in label-free high-throughput screening of protein-ligand interactions with timsTOF MALDI PharmaPulse
The timsTOF MALDI PharmaPulse® (timsTOF MPP) represents an advanced label-free high-throughput screening (HTS) solution for small-molecule ligand binding assays. Leveraging MALDI mass spectrometry's speed and robustness, combined with Bruker's timsTOF technology, timsTOF MPP enables rapid, accurate, and high-resolution detection of protein-ligand interactions. Explore the results of a study describing the first-time application of timsTOF MALDI PharmaPulse® (timsTOF MPP) for high-throughput screening (HTS) of protein-ligand interactions using label-free affinity-selection mass spectrometry (AS-MS).
