Limit of free salicylic acid in aspirin tablets using the Kinetex 5 µm C18 under USP allowable adjustments

In this application note, Phenomenex presents the robust separation of aspirin (acetylsalicylic acid) and related impurity salicylic acid under the USP conditions. The application note demonstrates the potential method improvements that can be achieved per the allowable adjustments outlined in USP General Chapter <621> relative to the original column and conditions referenced in the monograph.