IP-HPLC of Risedronate

Risedronate, the active pharmaceutical ingredient in Actonel®, is a bisphosphonate drug used for the treatment and prevention of osteoporosis. In this application note, the analysis of risedronate is performed on an AscentisTM C18 column using a Fluka brand ion pair reagent. When ion pair chromatography is required, it is imperative to use the highest purity reagents available that produce clean baselines and reproducible separations.