IP-HPLC of Risedronate
8 Dec 2014Risedronate, the active pharmaceutical ingredient in Actonel®, is a bisphosphonate drug used for the treatment and prevention of osteoporosis. In this application note, the analysis of risedronate is performed on an AscentisTM C18 column using a Fluka brand ion pair reagent. When ion pair chromatography is required, it is imperative to use the highest purity reagents available that produce clean baselines and reproducible separations.
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Ascentis® C18 HPLC column, 3micron, 15cm L x 4.6mm ID
Sigma-Aldrich SupelcoThe Ascentis family of columns is the fourth generation of HPLC column technology from Supelco scientists. Ascentis columns are bonded on high purity, 100 Angstrom silica including 3, 5, and 10 micron particle size. Columns are designed for small molecule applications and are scalable from micro columns (1.0 mm I.D.) to preparative dimensions (50 mm I.D.). The family includes C18, C8, Phenyl, Si and embedded polar group phase, RP-Amide. The Ascentis C8 is a highly reproducible column with excellent selectivity towards polar compounds. The phase excells in highly aqueous mobile phases as well as high organic mobile phases.