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Improving the Cleanliness of DBS Extracts using the Ostro 96-well Sample Preparation Plate and Single Step Method

30 Jan 2015

In this work, whole blood samples containing risperidone, its hydroxylated metabolite, 9-OH risperidone, and the internal standard, clozapine were extracted in both the traditional manner and in-well using a 96-well Ostro sample preparation plate.

Xevo TQ-S

Waters

Xevo TQ-S tandem quadrupole mass spectrometer - designed for the most demanding quantitative UPLC/MS/MS applications. The ultimate in tandem quadrupole performance allows you to achieve unrivalled sensitivity and robustness, available to everyone due to the accessibility of the Xevo platform. The Xevo TQ-S gives you class leading sensitivity and robustness, qualitative information when you need it most and accelerated method development for sensitive and robust methods. Reducing complexity, increasing ease of use, and ensuring the correct result every time.

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Ostro Sample Preparation Products

Waters

Ostro™ 96-well plate provides a novel solution for the cleanup of phospholipids in plasma and serum. Requiring minimal to no method development and using a simple protocol, this technology can be quickly implemented in order to optimize your laboratory's workflow. Removes significantly more phospholipids for cleaner extracts Improves reproducibility for more consistent, robust methods Increases throughput with easy-to-implement protocol

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Improving the Cleanliness of DBS Extracts using the Ostro 96-well Sample Preparation Plate and Single Step Method