Improving physiological relevance in neurological disease drug development

17 Aug 2026

In this case study, discover how Concept Life Sciences is building more reliable, consistent in vitro assays for neurological disease drug development using ioMicroglia from bit.bio. The adoption has enabled Concept Life Sciences to achieve greater lot-to-lot consistency and scalability in their assays, and the team has successfully used ioMicroglia to optimize microglial phagocytosis assays and test the effects of various stimuli on microglial activity.

Plus, explore how the collaboration with bit.bio also provided valuable technical support, helping Concept Life Sciences integrate these cells into their workflows and build more complex, human-relevant models for their clients.

Resource details:
Resource type: Case Study
Page count: 8
Read time: 12 mins

ioMicroglia Human iPSC-derived microglia

bit.bio

ioMicroglia are human induced pluripotent stem cell (iPSC)-derived microglia, precision reprogrammed using opti-ox™ technology. Within 10 days post-revival, ioMicroglia are ready for experimentation, expressing (>90%) key markers, including TMEM119, P2RY12, and IBA1. ioMicroglia display key functional traits including phagocytosis and proinflammatory cytokine secretion and can be co-cultured with ioGlutamatergic Neurons™.

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NeuroscienceNeuroscience research investigates the neurological mechanisms underlying behavior, neurodegenerative diseases, and other brain conditions. Learn about the innovative technologies for bioimaging, electrophysiology, cell culture, chromatography and other techniques used in this field.NeurodegenerationNeurodegeneration refers to the progressive deterioration of the structure and function of the nervous system, often seen in diseases like Alzheimer's and Parkinson's. Research focuses on early detection and potential therapies. Explore neurodegeneration research tools in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.Drug DevelopmentDrug development refers to the process of bringing a new drug to market.