ResourceDrug Discovery & Development
HEPATOPAC cultures
31 Jul 2026BioIVT presents HEPATOPAC® as a validated New Approach Methodology for long-term hepatic ADME-Tox and disease modeling studies.
The platform uses a precisely micropatterned co-culture of primary hepatocytes and stromal cells to maintain liver-specific function for more than four weeks. This extended stability supports research involving low-clearance compounds, repeat dosing and chronic exposure that can be difficult to assess in conventional in vitro systems.
Backed by more than 45 peer-reviewed publications, HEPATOPAC combines a differentiated culture architecture with an established record across drug metabolism, safety assessment and mechanistic liver research.
Resource details:
Resource type: Application note
Page count: 2
Read time: 3 mins
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ADME-ToxicologyADME-toxicology (ADME-Tox) studies are used in pharmacology and pharmacokinetics to assess the activity/toxicity of drugs <i>in vivo</i> or <i>in vitro</i>. Find bioassays for absorption, distribution, metabolism, and excretion of drug molecules including cytotoxicity, transporter/permeability, metabolism and activity assays as well as hepatocytes and cell lines for ADME. Find the best ADME-toxicology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Drug MetabolismDrug metabolism is the enzymatic conversion within the body of pharmaceutical substances into other chemical compounds. The primary site for drug metabolism is the liver.Liver DiseasePharmacokinetics