ResourceSeparations

Fast lipidomic analysis with high resolution of the molecular species

28 Aug 2024

The lipid signature of biological samples, or lipidome, is remarkably different between health and disease states. Therefore, lipids are good candidates to produce potent biomarkers. Analysis of lipidomes deals with a large number of isomeric compounds, making comprehensive separation essential to generate a biologically informative datasets. Explore how YMC uses human plasma samples to demonstrate that separations under 10 minutes are possible with real samples using a less hydrophobic YMC Accura Triart C8 column with bioinert coating to facilitate higher levels of sensitivity and recovery.

Links

Tags

LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.BiomarkersBiomarkers are biological markers which can be measured and evaluated to indicate a biological state. The use of biomarkers in research and diagnosis can indicate a normal or disease state or drug response of cells / tissues. Biomarkers include genetic markers, cell surface markers such as antigens, antibodies or receptors and secreted molecules such as cytokines. An assay system is required for identification of biomarkers. :
Fast lipidomic analysis with high resolution of the molecular species