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Development of a Dilute-and-Shoot LC-MS/MS Method with 21 Opiates in Urine

21 May 2014

This poster demonstrates a simple dilute-and-shoot quantitative method of 21 opiates, metabolites and common glucuronides by liquid chromatography tandem mass spectrometry (LC-MS/MS), without the limitation of time-consuming hydrolysis. This method provides broad drug coverage, fast turn-around time and compares favorable to hydrolysis analysis.

Thermo Scientific TSQ Quantum Ultra Triple Stage Quadrupole Mass Spectrometer

Thermo Fisher Scientific

The Thermo Scientific TSQ Quantum Ultra mass spectrometer provides ultimate productivity for bioanalytical analysis. Faster method development at the highest possible specificity is routinely achievable with the TSQ Quantum Ultra™ mass spectrometer. Featuring the patented Thermo Scientific HyperQuad quadrupole mass analyzer system, the TSQ Quantum Ultra performs highly selective reaction monitoring (H-SRM), which provides greater analytical selectivity.

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Development of a Dilute-and-Shoot LC-MS/MS Method with 21 Opiates in Urine