Designing optimal bioassays for measuring ADCC & ADCP activity
13 Jun 2022Increased interest in therapeutic monoclonal antibody (mAb) development has led to the need for sensitive, reliable, and biologically relevant bioassays for measuring Fc-effector activity. In this application note, Svar Life Science presents the advantages of using iLite Fc-effector activity bioassays for measuring ADCC and ADCP activity in vitro.
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iLite® Fc Effector Activity Bioassays
Svar Life Science ABThe iLite® Fc Effector Reporter Gene Bioassays Portfolio offers a variety of reporter gene cell lines and target cells that can be used in MOA-reflective assays to measure the Fc effect of antibodies and other biologics that specifically bind and activate Fc receptors. Using a Luciferase reporter gene system offers a convenient and powerful way of measuring antibodies' in vitro efficacy in triggering ADCC and ADCP.